Tissue stimulating proteins for gums

Tissue stimulating proteins for gums DEFAULT


According to the U.S. Centers for Disease Control and Prevention, about half of all Americans will have periodontal disease at some point in their lives. Characterized by inflamed gums and bone loss around teeth, the condition can cause bad breath, toothache, tender gums and, in severe cases, tooth loss. Now, in ACS Nano, researchers report development of a membrane that helps periodontal tissue regenerate when implanted into the gums of rats.

To regrow lost gum tissue and bone, scientists have tried implanting pieces of polymers that form a protected niche near the root of a tooth, recruiting nearby stem cells and helping them differentiate into new gum and bone cells. However, a second surgery is usually required to remove the polymeric membrane, which can get in the way of the healing process. Although researchers have developed biodegradable membranes, these materials don't tend to work as well for re-growing periodontal tissue. Alireza Moshaverinia, Paul Weiss and colleagues wanted to develop a membrane that would enhance periodontal tissue regeneration and then be absorbed by the body when healing was complete.

The researchers made nanofibrous membranes of poly(ε-caprolactone), a biocompatible polymer already approved for medical applications. They then coated the membrane with polydopamine (PDA), a synthetic polymer that mimics the sticky protein that mussels use to attach to wet surfaces. In the lab, dental-derived stem cells adhered to the membrane and differentiated. The PDA coating also attracted calcium and phosphate ions, leading to early bone mineralization. When the researchers implanted the membranes into the gums of rats with periodontal defects, bone at the defect sites regenerated to normal levels within eight weeks. By this time, the membranes had degraded and were absorbed by the rats. Now, the researchers are working on adding other components to the membrane that aid healing and prevent infection.

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Materials provided by American Chemical Society. Note: Content may be edited for style and length.

Journal Reference:

  1. Mohammad Mahdi Hasani-Sadrabadi, Patricia Sarrion, Nako Nakatsuka, Thomas D. Young, Nika Taghdiri, Sahar Ansari, Tara Aghaloo, Song Li, Ali Khademhosseini, Paul S. Weiss, Alireza Moshaverinia. Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering. ACS Nano, 2019; DOI: 10.1021/acsnano.8b09623

Cite This Page:

American Chemical Society. "New technique could help regrow tissue lost to periodontal disease." ScienceDaily. ScienceDaily, 21 March 2019. <www.sciencedaily.com/releases/2019/03/190321092218.htm>.

American Chemical Society. (2019, March 21). New technique could help regrow tissue lost to periodontal disease. ScienceDaily. Retrieved October 23, 2021 from www.sciencedaily.com/releases/2019/03/190321092218.htm

American Chemical Society. "New technique could help regrow tissue lost to periodontal disease." ScienceDaily. www.sciencedaily.com/releases/2019/03/190321092218.htm (accessed October 23, 2021).

Sours: https://www.sciencedaily.com/releases/2019/03/190321092218.htm

Procedures that regenerate lost bone and tissue supporting your teeth can reverse some of the damage caused by periodontal disease.

Your periodontist may recommend a regenerative procedure when the bone supporting your teeth has been destroyed due to periodontal disease. These procedures can reverse some of the damage by regenerating lost bone and tissue.

During this procedure, your periodontist folds back the gum tissue and removes the disease-causing bacteria. Membranes (filters), bone grafts or tissue-stimulating proteins can be used to encourage your body's natural ability to regenerate bone and tissue.

Eliminating existing bacteria and regenerating bone and tissue helps to reduce pocket depth and repair damage caused by the progression of periodontal disease. With a combination of daily oral hygiene and professional maintenance care, you'll increase the chances of keeping your natural teeth – and decrease the chances of other health problems associated with periodontal disease.

Sours: https://www.perio.org/consumer/gum-disease-regenerative-procedure
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Regenerative Growth Proteins

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Growth Proteins for Bone and Gum regeneration

Due to recent advances in periodontal tissue engineering, Dr. Sanchez is now able to cost-effectively apply these new bioactive products to create more predictable healing and regeneration of lost tissues. These growth proteins are a biological product made up of a unique group of active proteins found in nascent tooth development, naturally and predictably regenerates lost tooth attachment.

Why are these Growth Proteins so Important?

Regenerative proteins allow the body to maximize and accelerate the natural healing process. Typically, the body sends many different types of cells to the wound to begin healing. Regenerative proteins send a signal to those types of cells. These cells are involved in a number of healing functions including forming blood clots and releasing growth factors (GF) at the wounded site.

Growth Factors (GF) stimulate stem cells to generate new tissue in order to repair the body. As the quantity of GF at the wound increase, so does the number of stem cells activated to produce new tissue. Therefore, it is clear that using regenerative proteins helps the body heal more quickly and efficiently.

Clinical Uses for Regenerative Proteins

Advantages of Regenerative Growth Proteins

It is safe.
Because these FDA approved proteins are Laboratory engineered and delivered sterile to the area, so the risk of disease transmission is not a concern.

It is convenient and non-invasive.
It can be order for each patient and kept in the refrigerator until the patient is ready for surgery. There no need to draw blood from patient before surgery to extract growth factors from blood.

It promotes faster healing.
By supersaturating the wound with regenerative growth proteins, tissue synthesis and regeneration increase.

It is easy to use.
Regenerative growth proteins makes bone substitute materials and bone grafting products more gel like, thus making them more easy to handle.

Frequently Asked Questions

How are Regenerative Growth Proteins made? 
These proteins are engineered in the laboratory therefore there is no risk for disease transmission.

Do I need Regenerative Growth Proteins for my procedure? 
Sometimes there is no need for Regenerative proteins. Dr. Sanchez will discuss your treatment options with you, including whether or not you would benefit from the use of this approach.

Will my insurance cover the cost of Regenerative Growth Proteins? 
Regenerative proteins are not typically covered by insurance. However, many find it cost efficient based on the benefits that treatment with growth factors provides.

Sours: https://www.periowestmn.com/rgp.php
Gum Recession Cure - How to Rebuild Gums

Advanced regenerative technologies for periodontal tissue repair

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Sours: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335769/

Proteins gums stimulating tissue for

Technology : Protein plugs gaps in gum disease

By Andy Coghlan

GUM tissue eaten away by disease can now be restored using a gel that rebuilds teeth’s vital supporting tissue. The gel, which is simple to apply during routine surgery, contains amelogenin, a structural protein which reawakens the processes that govern the growth of teeth in infants.

Patients suffering from periodontitis develop large gaps between their teeth and the surrounding tissue as bone and gum tissue is eaten away. Clinical trials with the gel show that on average, two-thirds of the tissue that has been worn away regrows in patients treated with the gel. In some cases, all the tissue originally lost grows back.

The gel, Emdogain, went on sale in the US last month and in Britain earlier this year. It is already on the market in several European countries including Sweden, where it was developed by Biora, a biotechnology company based in Malmö.

Dentists usually treat periodontitis with flap surgery, in which a small cut is made around a diseased tooth. After cleaning around the root, the gum is stitched to close the fissure. “You get rid of the pocket, but you don’t get any recovery in the tissue supporting the tooth,” says Tomas Hammargren, the president of Biora.


Dentists apply Emdogain during flap surgery by injecting it through the cut to coat the exposed root. Within two days the gel, a modified version of a polymer found in seaweed, biodegrades to leave a coating of amelogenin on the root surface.

“It sets off a chain reaction that rebuilds the supporting tissue,” says Hammargren. First, the protein coating attracts cementoblasts, cells which form another thin coating on the roots called the cementum. Next, ligaments grow into the cementum, anchoring it to bone tissue surrounding the tooth.

More than 300 patients with advanced periodontitis were included in the trials, which were conducted at clinics in the US and Sweden. All had gaps of 5 millimetres or more between their teeth and the surrounding tissue. The trials showed that the gel made worn bone tissue regrow, as well as soft gum tissue. “You get tissue back, so the hole closes up,” says Hammargren. Within 16 months, two-thirds of lost tissue had grown back in treated patients, rising to as much as 70 per cent or more after three years. Some patients regained all the lost tissue.

No such regrowth was seen in patients who received a placebo, and some untreated patients suffered further tissue loss. In half the clinical trials, dentists treated neighbouring teeth in the same jaw either with a placebo or the active gel. This made it easier to show that the gel was working.

Results of these trials-which convinced regulatory authorities in the US, Europe and Japan to approve the gel for sale-are to be published later this year in a special issue of The Journal of Clinical Periodontology.

Gareth Griffiths, secretary of the British Society of Periodontology and lecturer in periodontology at the Eastman Dental School in London, is impressed with the results of Biora’s studies. He says that the method of applying the gel is less fiddly than alternative techniques under development. These require the insertion of membrane barriers to prevent soft gum tissue from rapidly growing into the gap, so giving the ligaments and bone more time to re-establish themselves.

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Sours: https://www.newscientist.com/article/mg15420813-800-technology-protein-plugs-gaps-in-gum-disease/
Tissue Regeneration Using Nature's Way

I want to go with you - came to Vitka's ears. In the dim light of a blue light hanging over the door of the ward, he saw how Misha tore the same blanket out of Masha's. Hands, threw it aside on the floor and lay down on Masha, who was lying on her back.

Now discussing:

She was embarrassed, then smiled and thanked. Then she got up and went to the bathroom. I guessed why, seeing a wet spot on the spot where she was sitting.

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