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Most Effective Diet Pill 2016


Do any weight loss pills really work?

When it comes to weight loss, there is no shortage of pills, drinks, and supplements claiming to help the weight fall off. But do weight loss pills help, and are they safe?

The best weight loss pills may contain one or more active ingredients intended to increase fat burning, decrease appetite, or reduce absorption of fat.

Not all weight loss pills and supplements are created equal. Certain pills may cause unpleasant side effects while others may not be proven to result in weight loss.

We will look at the following nine weight loss pills and supplements:

  • Alli (orlistat)
  • caffeine
  • glucomannan
  • garcinia cambogia extract
  • pyruvate
  • green tea extract
  • conjugated linoleic acid
  • Hydroxycut
  • prescription weight loss pills

1. Alli (orlistat)

Alli is the brand name for the drug orlistat. It is one of the most popular weight loss pills.

Orlistat is available as a prescription drug and also sold over the counter. It works by preventing the body from breaking down of some of the fat that people eat. When the intestines absorb less fat, weight loss may occur.

A review of indicated that orlistat might increase weight loss by a small amount. The review found that those who took orlistat lost an average of 2.9 percent more weight than those who did not take the drug.

Orlistat may cause a change in bowel habits. People taking orlistat may experience side effects, such as diarrhea, stomach pain, and difficulty controlling bowel movements.

2. Caffeine

Caffeine is a stimulant found in coffee, tea, soft drinks, and chocolate. It is also often added to diet pills and supplements.

According to of 76 obese adults, people who had high caffeine intake saw a greater reduction in fat mass, weight circumference, and overall weight compared to those who had low caffeine intake.

Side effects of caffeine include jitteriness, increased heart rate, and trouble sleeping.

3. Glucomannan

Glucomannan is a type of fiber supplement. It works by absorbing water in the gut, leading to a feeling of fullness that may prompt people to eat less.

Studies appear to be conflicting on whether glucomannan can aid in weight loss, however.

of 176 people indicated that glucomannan contributed to weight loss in healthy, overweight adults.

However, a more recent review of randomized control trials indicated that glucomannan did not appear to result in significant weight loss.

For those who do take glucomannan, side effects may include gas, diarrhea, and stomach pain.

4. Garcinia cambogia extract

Garcinia cambogia is a fruit that contains hydroxycitric acid, which is thought to help weight loss.

Garcinia cambogia extract contains the juices from this small fruit and is available as a weight loss pill. Garcinia cambogia may inhibit or prevent a fat-producing enzyme called citric acid lyase.

There is little scientific evidence to support the use of this extract to help with weight loss. According to , the effectiveness of the extract in long-term clinical trials and large-scale studies has not been proven.

Although garcinia cambogia extract may not aid in weight loss, it does not appear to cause many side effects when taken in reasonable doses. The report above also indicated that adverse effects did not occur with a dietary dosage of up to 2,800 milligrams (mg) per day.

5. Pyruvate

The body produces pyruvate when it breaks down sugar. Pyruvate is also sold as a supplement to assist with weight loss by helping break down fat and boosting metabolism.

According to the National Institute of Health’s , pyruvate may have some effects on weight loss. Existing studies are weak, so results are not conclusive.

Side effects of pyruvate include gas and bloating.

6. Green tea extract

Many diet pills contain green tea because it may increase the body’s ability to burn fat, and especially fat in the stomach area.

Although more evidence is needed, some research indicates that drinks containing green tea extract may promote the loss of fat around the stomach area. The increase in fat loss may also result in modest weight loss.

Although green tea extract is usually well tolerated, it can cause stomach pain, constipation, and nausea.

7. Conjugated linoleic acid

Conjugated linoleic acid is a type of fatty acid found mostly in beef and dairy. It has been marketed as one of the best weight loss pills for its potential to boost metabolism and decrease appetite.

However, the majority of the studies on conjugated linoleic acid leading to weight loss have been carried out on animals. According to of research, weight loss appears to be minimal in human studies.

Conjugated linoleic acid appears to be safe in doses of up to 6 grams per day for up to 12 months. Possible side effects include stomach discomfort, diarrhea, or constipation. It may not be suitable for people who have diabetes.

8. Hydroxycut

Hydroxycut is a popular dietary supplement. There are different Hydroxycut products, which contain various ingredients. Hydroxycut products typically contain plant extracts and caffeine, although caffeine-free versions of the supplement are also available.

There are no studies that review Hydroxycut specifically. Caffeine, which has been studied, may contribute to small amounts of weight loss.

Since the ingredients of Hydroxycut vary, it is difficult to state the possible side effects. Hydroxycut supplements that contain caffeine may cause nervousness and increased heart rate.

Hydroxycut is considered a supplement and does not go through the same rigorous testing as drugs to determine its safety.

9. Prescription weight loss pills

Certain weight loss pills are only available through a doctor’s prescription. Although there are various pills on the market, most weight loss medications work by making it harder to absorb dietary fat or by suppressing the appetite.

A common weight loss pill is Qsymia.

Prescription pills may lead to some weight loss, but they can have side effects. Depending on the prescription, side effects of weight loss pills can include stomach pain, dry mouth, and diarrhea.


When it comes to the best weight loss pills, it appears there is no magic bullet. Although some of the diet pills and supplements mentioned above may contribute to weight loss, the amounts are usually modest.

Caffeine, green tea extract, and orlistat appear to have the most research to back up their claims.

Some weight loss pills can also lead to side effects, with the most common being stomach discomfort and changes in bowel movements.

Dietary supplements do not face the same scrutiny as drugs that are approved by the United States Food and Drug Administration (FDA), so their safety is not always fully understood. Before taking any supplement for weight loss, it is best to talk with a doctor or other healthcare professional.

The best bet for people trying to lose weight is to reduce portion size, eat lean protein and veggies, and get regular exercise.

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Complete Guide to Prescription and Over the Counter Diet Pills

Are you thinking about using an over-the-counter weight loss pill? Or perhaps you are interested in a weight loss medication that requires a prescription. Deciding whether a weight loss pill, prescription, or supplement is right (and safe) for you requires understanding how they work, their side effects, and effectiveness. All of these medications are typically prescribed along with lifestyle modifications and behavioral changes.

The best resource for information regarding the use of any supplement or weight loss pill is your healthcare provider. They will also be able to discuss how taking a diet pill might interact with your other medications and provide the best advice regarding the safety of certain products.

Types of Weight Loss Pills 

There are two different types of diet pills. They are prescription weight loss pills and over-the-counter (OTC) weight loss pills, the latter of which also include herbal supplements.

Prescription weight loss pills are medications that you get through your doctor. OTC diet pills and herbal weight loss supplements can be purchased without a prescription and are available in many vitamin shops and drugstores.

Generally speaking, both prescription and OTC weight loss pills have one of three goals:

  • To reduce your appetite, making it easier to make healthy food choices
  • To increase your body's ability to burn fat, creating a larger calorie deficit
  • To inhibit your body's ability to absorb the fat in the foods you eat

FDA Approval

Some diet pills are approved by the U.S. Food and Drug Administration (FDA). Others don't require FDA approval. This chart outlines what it means to have FDA approval, as well as what it means if a diet pill is not approved by the FDA.

FDA-Approved Drugs
  • Proven to be safe

  • Proven to be effective

  • Meets federal quality standards

  • Benefits outweigh the risks

Drugs Not Approved by the FDA
  • Safety not reviewed or approved

  • Effectiveness not reviewed or approved

  • Claims of what the product can do are not approved or verified

It is also important to realize that some diet pills contain ingredients not listed on their labels which are also not approved by the FDA.

A 2018 study looked at 317 different weight loss products and found that 269 of them (84.9%) contained sibutramine—an ingredient that the FDA removed in 2010—as a hidden ingredient. Though this substance helps reduce appetite short term, it has also been connected with mood changes, increased blood pressure and heart rate, and even amnesia.

Other hidden ingredients found in some of the weight loss pills studied were:

  • Phenolphthalein, a laxative that the FDA removed in 1999
  • Fluoxetine, a prescription antidepressant also known as Prozac
  • Ephedra, a substance banned in dietary supplements since 2004
  • Belviq, a drug the FDA requested be removed from the market in 2020

The availability of diet pills via the internet has made these substances even harder to regulate and control. It also makes it more difficult to determine whether the product you buy has safe dosage levels, potentially increasing your risk of taking a toxic amount.

Herbal supplements are not considered medications and, therefore, do not have to follow the strict safety guidelines that govern medicines.

Prescription Diet Pills 

The U.S. Food and Drug Administration (FDA) has approved a range of medications designed to help with weight loss. These use different mechanisms and may only be appropriate for certain people.


How it works: Approved by the FDA in 1999,Xenical (orlistat) is a lipase inhibitor. This means it works by decreasing the absorption of fat, which the body then eliminates in the stool.

Effectiveness: One study of 400 people taking 120 mg of orlistat three times per day reported that users significantly reduced their weight, with 27.4% losing at least 5% of their beginning weight. A 2018 review found that the average weight loss with orlistat is 2.9 kg (6.4 pounds).

Side effects: The most common side effects are gastrointestinal (loose stools, stomach pain) from undigested fat in stools, especially if a low-fat diet is not followed. Other potential effects include headache, anxiety, and irregular menstrual periods.

Who may benefit: This weight loss drug is often prescribed for people who are overweight and might also have other medical conditions, such as high blood pressure or cholesterol, diabetes, or heart disease.

Risks: Orlistat may cause damage to the liver and/or kidneys. It also blocks the absorption of beta-carotene and some of the fat-soluble vitamins, making a multivitamin necessary to ensure that your body gets enough of these nutrients.


How it works:Qsymia contains two substances: phentermine and topiramate. Phentermine (which is released immediately) impacts food intake by increasing norepinephrine in the body. Topiramate (which is released later in the day) is thought to suppress appetite and increase energy. 

Effectiveness: Both phase I and phase II trials have found that the phentermine-topiramate combination aids in weight loss, with the average loss of roughly 10% of starting body weight.

Side effects: Actual effects can vary depending on the dosage prescribed, with some of the most common being dry mouth, constipation, tingling or prickling of the skin, insomnia, irritability, and changes in taste. Some people also experience headaches, insomnia, depression, anxiety, fatigue, and blurred vision.

Who may benefit: Your physician may prescribe Qsymia if you have a body mass index (BMI) over 30, or a BMI of 27 or higher along with a weight-related condition such as type 2 diabetes or high blood pressure.

Risks: Exposure to this drug combination during pregnancy may increase the risk of the baby being born with cleft lip or cleft palate.


How it works:Saxenda (liraglutide), is an injectable medication that reduces food intake by decreasing appetite and increasing feelings of fullness. 

Effectiveness: A 2016 review found that, after one year, the average user lost between 8.9 pounds and 13.3 pounds. Another study noted that almost two-thirds of users decreased their body weight by 5% or more, one-third lost at least 10% of their body weight, and 14 out of 100 participants lost 15% of their body weight.

Side effects: Gastrointestinal side effects (nausea, diarrhea, constipation) are the most common with Saxenda, especially when first taking the drug. Other potential effects include headaches and low blood sugar.

Who may benefit: Saxenda is designed to be used by people who have obesity (with a BMI of 30 or more) or by people who have a BMI of 27 or more and a weight-related medical condition such as type 2 diabetes, high cholesterol, or high blood pressure.

Risks: Gallbladder disease, acute pancreatitis, and severe hypoglycemia are a few safety concerns associated with Saxenda. This drug shouldn't be taken by people who take insulin, people who are breastfeeding, or those with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2.


How it works:Contrave (a combination of naltrexone hydrochloride and bupropion hydrochloride) affects the central nervous system to increase the number of calories burned and reduce appetite. This pill is often prescribed along with a reduced-calorie diet and exercise program.

Effectiveness: Research indicates that people taking Contrave lose more weight than those taking a placebo, with a mean loss of 5.4% of initial body weight, and they typically maintain that loss for at least 56 weeks.

Side effects: The most common side effects are nausea, vomiting, diarrhea or constipation, headache, dizziness, insomnia, and dry mouth. The buproprion in Contrave can also cause suicidal thoughts or actions, particularly when first taking it.

Who may benefit: Contrave is designed for people with a BMI of 30 or higher, or those with a BMI of 27 and up with another weight-related medical condition.

Risks: Contrave may increase your risk of seizures, increased blood pressure or heart rate, low blood sugar, liver damage, visual issues, and manic episodes.


How it works: Phentermine—which is marketed under a long list of names, including Suprenza, Adipex-P, and Lomaira—works by decreasing appetite.

Effectiveness: A 2013 controlled trial reported that 43.3% of subjects taking 7.5 mg phentermine lost at least 5% of their body weight, with 46.2% of those taking 15 mg achieving the same effect. A 2019 study adds that taking this drug for three months or more can provide greater weight loss.

Side effects: Side effects can include insomnia, diarrhea or constipation, vomiting, an unpleasant taste, and dry mouth.

Who may benefit: Like many of the other prescription weight-loss drugs, phentermine is designed for people with a BMI of 30 or higher, or those with a BMI of 27 who have other weight-related medical conditions.

Risks: This drug should not be used by people who are pregnant or nursing, or those with cardiovascular disease, hyperthyroidism, glaucoma, or a history of drug abuse.


How it works: Wegovy, a weekly injection of semaglutide, works by reducing appetite, decreasing calorie intake. It activates areas of the brain responsible for appetite regulations and food intake.

Effectiveness: Trials showed that treatment with Wegovy produced a statistically significant reduction in body weight over the course of 68 weeks. Subjects lost 14.9% of body weight compared to 2.4% with placebo.

Side effects: The most common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, and gastroesophageal reflux disease. It can also cause hypersensitivities such as anaphylaxis, retinopathy in diabetics, heart palpitations, or a racing heartbeat. Suicidal ideation is also a potential side effect, as seen with other weight loss medications.

Who may benefit: Wegovy may benefit adults with a starting BMI of greater than 30 (obesity) or greater than 27 (overweight) who have at least one weight-related health condition such as hypertension, type 2 diabetes mellitus, or dyslipidemia.

Risks: This drug should not be used by people who are pregnant or who are planning to become pregnant. Personal or family history of medullary thyroid carcinoma (MTC) or patients with m ultiple endocrine neoplasia type 2 (MEN 2) should not take Wegovy. Nor should patients who have had a previous hypersensitivity reaction to semaglutide or any of the ingredients in Wegovy.

Over-the-Counter Diet Pills and Supplements

When purchasing a non-prescription weight loss aid, it's important to know that while OTC medications are FDA-approved for safety and effectiveness, weight loss supplements are not. It's the responsibility of supplement manufacturers to ensure that these products are safe.

For this reason, it is important to be careful when buying a diet supplement or popular herbal supplement for weight loss. The FDA also does not approve most of the claims that companies make about their products. In many cases, weight loss claims are carefully crafted to make the product sound more effective than it is.


How it works: The only over-the-counter weight loss pill approved by the FDA,Alli, contains a lower dose of orlistat (60 mg), the same medication that is in Xenical. It works by reducing the body's absorption of fat.

Effectiveness: One review of 33 randomized controlled trials involving 9,732 participants reports that orlistat provides a "slight but significant decrease in body weight." A 2014 assessment indicates that the amount of weight lost at the one-year mark is around 3 kilograms (6.6 pounds) when combined with a low-calorie diet.

Side effects: People who take Alli may experience uncomfortable gastrointestinal side effects, which can be minimized by following a less than 30% fat diet.

Who may benefit: This OTC weight loss drug is for adults with a BMI of 25 or above and should be combined with a low-calorie, low-fat diet.

Risks: Alli should not be used by people who are pregnant or breastfeeding, people who have had an organ transplant, those who've been diagnosed with food absorption issues, or those taking cyclosporine. Orlistat may increase the risk of kidney damage and osteoporosis, and it may also interact with some drugs, such as warfarin and antiretroviral medications.

Alli was voluntarily removed from the market in 2014 after a tampering scare, but the company re-released it with a tamper-evident package in 2015.

Garcinia Cambogia

How it works:Garcinia cambogia is derived from a fruit that grows in warmer climates and is said to assist with weight loss by reducing appetite.

Effectiveness: Claims made by sellers have not been supported by scientific research. There is little evidence to support its effectiveness. A review published in 2015 reports that results are mixed—some people appear to lose weight with this substance while others do not.

Side effects: Adverse effects associated with taking garcinia cambogia can include headache, nausea, diarrhea, and other gastrointestinal issues.

Who may benefit: Studies that have found garcinia cambogia effective for weight loss report that this effect is the same regardless of age, sex, or any other weight-related conditions. It may be better at reducing visceral fat (belly fat) than some other substances.

Risks: While rare, the use of this substance may result in liver damage, and it is unclear whether it is safe for people who are pregnant or breastfeeding.


How it works: The name of this diet supplement may not sound familiar, but you've probably seen products that contain glucomannan, which is basically a fiber supplement. Lipozene is one.

Effectiveness: In 2020, authors of a review study reported that they could not confirm that this fiber substance can actually promote weight loss.

Side effects: People taking glucomannan may notice that they belch more often and feel bloated, as well as having feelings of stomach fullness—at least for the first few days. Diarrhea and constipation might also occur, particularly when taken in higher doses.

Who may benefit: Some studies that connect glucomannan with weight loss show more positive findings in female subjects, with even greater effects when this supplement is combined with garcinia cambogia.

Risks: The EFSA Panel on Food Additives and Nutrient Sources states that this supplement presents no concern for being toxic or allergenic as long as dosing stays below 3 grams per day.

On January 10, 2020, the FDA announced that glucomannan would be added to the definition of dietary fiber (after receiving a petition from a citizen), enabling it to be included on products' Nutrition and Supplement Facts labels.

Conjugated Linoleic Acid (CLA)

How it works:Conjugated linoleic acid (CLA) occurs naturally in meat, dairy, and vegetable oil and is thought to assist with weight loss, in part, by reducing the body's absorption of fat.

Effectiveness: A 2016 review of seven studies concluded that CLA might promote weight loss, but the difference in taking this substance versus taking a placebo is relatively small. Another 2016 study found that some people who took a CLA supplement experienced increased insulin resistance and lower HDL cholesterol levels.

Side effects: Potential side effects include constipation, diarrhea, soft stools, and abdominal pain.

Who may benefit: CLA has been found to provide anti-inflammatory effects and improved lipid profiles.

Risks: Some people have experienced a myocardial infarction (heart attack) after taking CLA, so this supplement might not be advised for people with heart issues.

Raspberry Ketones

How it works:Raspberry ketones come from red raspberries (it gives them their smell). The claim is that the product can reduce weight by breaking down and reducing fat storage, and increasing metabolism.

Effectiveness: This weight loss supplement became popular after Dr. Oz mentioned it on his TV show, but there is not enough evidence to support the claims that raspberry ketones can help humans lose weight.

Side effects: People taking raspberry ketones may feel jittery and have increased blood pressure and heart rate.

Who may benefit: It is currently unclear whether this dietary supplement offers any real health benefits. Plus, many products contain a much higher amount than has been determined safe (100 mg per day).

Risks: Research suggests that raspberry ketones may be associated with coronary vasospasm, which is when the coronary arteries suddenly constrict and reduce blood flow to the heart. Additional studies indicate that this supplement may interfere with the medication warfarin and be unsafe for people who are pregnant or lactating.


How it works:Forskolin is an extract from the coleus forskohlii plant advertised as a diet supplement, carb blocker, and fat burner.

Effectiveness: Some studies have found that forskolin may help with weight loss, whereas others have found it doesn't, so its effectiveness is not yet proven.

Side effects: Side effects can include increased bowel movements and loose stool and generally reduce over time.

Who may benefit: One small study found that people taking forskolin had increased HDL cholesterol levels (the "good" cholesterol) and improvements in their insulin concentration and resistance when combined with a low-calorie diet.

Risks: This supplement may pose risks for people with polycystic kidney disease.


How it works: Meratrim is a mixture of extracts taken from the flower heads of the Sphaeranthus indicus plant and the fruit rind from Garcinia mangostana and is thought to help reduce weight by reducing appetite.

Effectiveness: A study of 60 participants with a mean BMI of 28.3 found that those taking Meratrim had greater reductions in their weight as well as in the size of their waist and hips.

Side effects: While some study participants did experience nausea, stomach pain or discomfort, and gastritis, researchers concluded that these effects were not related to Meratrim use because the placebo group also experienced effects. In a 2013 study, some participants experienced headaches, nausea, gastrointestinal issues, and various body pains, but, again, these were not attributed to Meratrim since the placebo group experienced them too.

Who may benefit: The 60-participant study also reported that those taking Meratrim had "significant" changes in their LDL cholesterol (the "bad" cholesterol), triglycerides, and total cholesterol.

Risks: Research indicates that, while the risk appears to be small, Garcinia-based supplements may be linked to liver damage, serotonin toxicity, and mania.


How it works: Sometimes referred to as chromium picolinate, products that contain this substance often claim to help improve calorie burn and decrease appetite.

Effectiveness: While some research has shown a small correlation between chromium and weight loss, there is insufficient evidence to support a more substantial claim.

Side effects: In some trials, people taking chromium have reported watery stools, constipation, nausea, vomiting, headache, vertigo, and hives.

Who may benefit: Chromium is considered an essential nutrient and may have some antioxidant effects.

Risks: Chromium is generally considered safe as long as it is not consumed in high amounts. It may interact with some medications, such as insulin, antidiabetes medicines, and some hypothyroidism medications.

Green Tea

How it works:Green tea can be consumed as a beverage or in pill form and claims to increase metabolism, resulting in weight loss.

Effectiveness: While green tea is safe when consumed in moderation, little evidence supports its use as a long-term weight loss supplement.

Side effects: Green tea as a beverage is generally well-tolerated, but people taking green tea extract may experience constipation, nausea, abdominal discomfort, and increased blood pressure.

Who may benefit: Green tea is rich in polyphenols and may provide anti-inflammatory, antioxidant, and anti-cardiovascular effects.

Risks: Some researchers have expressed concerns that green tea extract may cause liver damage.

Green Coffee Bean Extract

How it works:Green coffee is another name for raw coffee beans (so this type of product does contain caffeine). It is thought to inhibit the body's storage of fat and/or reduce appetite.

Effectiveness: A study of 64 women with obesity found that while they all lost weight on a low-calorie diet, those who received 400 mg of green coffee bean extract for eight weeks lost more weight than those who did not take the extract. They also had lower total cholesterol and LDL, or "bad" cholesterol levels.

Side effects: Reported adverse effects include headache and urinary tract infections.

Who may benefit: One review concluded that green coffee extract could improve fasting blood glucose levels, insulin levels, and total cholesterol.

Risks: Consuming 200 mg of green coffee bean extract per day is generally considered safe, though this has not been adequately studied.


How it works: This herb is extracted from a flowering cactus plant (hoodia gordonii) and sold as an appetite suppressant. It can be consumed in tablet, pill, or powder form.

Effectiveness: A 2021 review reports there is insufficient scientific evidence to support the claims that hoodia is an effective form of long-term weight management.

Side effects: Some people taking hoodia have experienced nausea, vomiting, dizziness, and strange skin sensations.

Who may benefit: Hoodia may provide positive effects for people with metabolic diseases.

Risks: Hoodia may be unsafe for some people due to its effects on blood pressure, bilirubin, and heart function.

Bee Pollen

How it works: Bee pollen has been found to speed up fat metabolism, thus making it an appealing weight loss supplement.

Effectiveness: There is little evidence supporting bee pollen's use for weight loss, particularly because many studies have been conducted on animals versus humans.

Side effects: The main side effect concern with bee pollen is if you are allergic, which can result in hives, wheezing, and anaphylaxis—especially if you've had a serious reaction to bee stings.

Who may benefit: Bee pollen has several beneficial health properties, including being an anti-inflammatory, antimicrobial, and antifungal substance.

Risks: In 2014, the FDA flagged the company Oasis Bee Pollen for making false and misleading claims about its product's weight loss effects. The FDA also warned of hidden ingredients in the company's supplement, including sibutramine, which can increase blood pressure, and phenolphthalein, which can cause cancer.

If the over-the-counter diet pills or weight loss supplements you're interested in are not listed above, visit the National Institutes of Health Office of Dietary Supplements. The NIH provides a comprehensive list of diet supplements and current information about the safety and effectiveness of each one.

Banned Weight Loss Drugs

There are a few drugs that the FDA has banned for consumer use.


After ephedra was banned in 2004 due to its health risks, several similar stimulants took their place. Most advertise that they are ephedra-free and safe.

These often contain bitter orange (citrus aurantium), synephrine, or octopamine. Two of the most popular products, Xenadrine EFX and Advantra Z, were tested by researchers in 2005 and still found to have unsafe effects on heart rate and blood pressure.


Meridia (sibutramine), an appetite suppressant, was removed from the market in the United States in 2010. The FDA initially approved the product, but the manufacturer stopped producing it after clinical studies showed that users had an increased risk of heart attack and stroke.


This drug was part of the anti-obesity medication fen-phen and worked by reducing carbohydrate cravings. However, the FDA withdrew its approval in 1997 after receiving numerous reports that women taking this drug had developed valvular heart disease.


This appetite suppressing drug—also known as Redux— was approved for a short period of time in the 1990s. Still, the FDA ultimately withdrew its approval after concerns about its effects on the cardiovascular system. Like fenfluramine, it appeared to cause valvular heart defects.


Belviq (lorcaserin) worked by activating serotonin receptors that regulate hunger. It was available with a prescription to patients with a BMI of 30 or a body mass index of 27 along with an obesity-related condition. In 2020, however, the FDA recalled Belviq from the market, citing cancer risks.

The fact that these banned drugs were once approved by the FDA serves as a reminder that even with FDA approval, there can be unknown risks of taking weight-loss drugs.

Factors to Consider

There are a few factors to think about before deciding to buy and use weight loss medications. These include:

  • Your medical history: Taking weight loss pills could be dangerous for people with some conditions, such as heart disease, liver disease, hyperthyroidism, or glaucoma.
  • Other medications you take: Some diet pills may interact with other drugs, either intensifying or reducing their effects.
  • Allergies: If you are allergic to any substances that could potentially be included in the weight loss pill, it's important to avoid taking it.
  • If you are pregnant or breastfeeding: You could potentially pass the ingredients on to your newborn or unborn child.

A Word From Verywell

Diet and lifestyle changes are usually the best way to support lasting weight loss and maintenance. However, there are instances when health care providers may suggest weight loss supplements or prescription medications based on your individual needs.

Always talk to your doctor about any diet pill or weight loss supplement that you are considering. This helps ensure that it is safe for you, given your health and physical condition.

Questions to Ask Your Doctor About Weight Loss

Thanks for your feedback!

Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

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Additional Reading
  • Ebrahimi-Mameghani M, Jamali H, Mahdavi R, Kakaei F, Abedi R, Kabir-Mamdooh B. Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial. Croat Med J. 2016;57(4):331-42. doi:10.3325/cmj.2016.57.331

  • Farrington R, Musgrave IF, Byard RW. Evidence for the efficacy and safety of herbal weight loss preparations. J Integr Med. 2019;17(2):87-92. doi:10.1016/j.joim.2019.01.009

New Weight Loss Pill for Obesity?

5 Best Diet Pills For Women to Lose Weight Fast

However, not all diet pills for women are created equal. Although some products deliver great results, many of the best-selling weight loss pills don’t have the right combination of ingredients to be effective, or they aren’t dosed at the correct amount.

Luckily, we’ve reviewed the most popular weight loss pills for women to see which products live up to the hype and which ones are a waste of money. We evaluated each supplement based on its ingredients, benefits, customer reviews, price, and guarantee.

After countless hours of research, we’ve narrowed down our list to the 5 best weight loss supplements for women. If you’re ready to burn stubborn body fat, improve your energy levels, and feel more confident than ever, here are the best weight loss pills for women.

2021’s Best Diet Pills for Women

#1) LeanBean: Best Weight Loss Pills Overall


LeanBean is the best diet pill for women looking to burn fat, increase energy, and reduce hunger cravings. This weight loss pill is formulated with natural ingredients, and it is designed exclusively to address women's specific weight loss needs. LeanBean also offers a 90-day money-back guarantee.

LeanBean contains four appetite suppressants, including a full 3 grams of glucomannan, which is FDA approved for healthy weight loss. Unlike most weight loss pills, LeanBean contains no pure caffeine and is very low in stimulants, so it's a great weight loss supplement for women who want to avoid caffeine and other ingredients that cause jitteriness.

How Does It Work?

LeanBean works in three ways to help you lose weight.

Appetite Suppressant: First, a healthy dose of appetite suppressant helps reduce cravings by making you feel fuller between meals. You can naturally reduce your calorie intake because you will be less inclined to eat.

Boost Metabolism: Second, LeanBean uses a blend of natural thermogenics and minerals to boost your metabolism. An increased metabolic rate kickstarts the fat-burning mechanism of your body as it uses fat as a fuel source.

Boost Energy and Well-being: Third, LeanBean contains a vitamin complex to provide a clean energy boost that will help you exercise more effectively. The vitamins also help guard against any nutrient deficiencies.


  • Konjac fiber (glucomannan)
  • Green coffee
  • Turmeric
  • Chromium picolinate
  • Garcinia Cambogia extract
  • Choline
  • Vitamin B6 & B12
  • Zinc
  • Chloride
  • Acai berry
  • Piperine

LeanBean recommends taking two capsules, three times per day. For best results and to help you feel full, you should drink a glass of water with each dose.

Who Is This Product For?

LeanBean is the ideal weight loss pill for women who want to get rid of belly fat without too much hard work. It's an all-natural weight loss supplement that is effective for both appetite suppression and fat burning. Its low-stimulant formula contains no pure caffeine, so it's a great fit for women who want to stay away from stimulants. It also contains no animal products, making it a good choice for vegans.

  • Natural weight loss pills that actually work
  • Designed specifically for women to lose weight
  • Effective for boosting metabolism and burning more calories per day
  • 100% natural ingredients
  • Money back guarantee

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#2) PhenQ: Best Diet Supplement for Losing Over 30 Pounds


PhenQ is a leading weight loss pill that takes a multi-pronged approach to helping you achieve your weight loss goals. Its special combination of ingredients enables it to address several factors for effective weight loss. It is great for fat burning, blocking fat production, appetite suppression, and improving energy and mood.

With all these perks, it's no surprise that PhenQ is our choice for women who want to lose more than 30 pounds. PhenQ claims nearly 200,000 satisfied customers worldwide, and the customer reviews are indeed quite impressive.

Clinical trials have shown that PhenQ is effective in burning body fat, reducing weight, and improving muscle mass. This weight loss supplement is made in the United States and the United Kingdom in FDA- and GMP-approved facilities. It comes with a 60-day money-back guarantee.

Results to Expect from PhenQ

  • Burn stored fat
  • Suppress appetite
  • Block fat production to stop weight gain
  • Improve mood and energy levels

How Does It Work?

PhenQ works by targeting multiple factors for weight loss. The proprietary formula α-LACYS Reset® works in tandem with other weight loss ingredients to boost metabolism and increase thermogenic fat burning. Piperine helps stop the formation of new fat cells.

Nopal cactus is a great source of amino acids and fiber, which helps suppress appetite by giving you that full feeling. And Chromium picolinate helps to reduce sugar and carb cravings, making it easier to resist temptation.

PhenQ also contains 150mg of caffeine per serving, which is more than most other weight loss pills. Caffeine has many weight loss benefits: it reduces hunger, boosts energy levels, and is a thermogenic fat burner. Ingredients

  • α-LACYS Reset®
  • Capsicum
  • Piperine
  • Niacin
  • Chromium picolinate
  • Caffeine
  • Nopal
  • L-Carnitine fumarate

The ideal dosage for PhenQ is simple—just two capsules a day to start achieving your weight loss goals.

Who Is This Product For?

If you hope to get rid of more than just a few pounds and undergo a serious transformation, the multi-angle approach of PhenQ might be for you. The energy boost will also help you crush gym sessions.

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#3) TrimTone: Natural Diet Pill That Works Fast


TrimTone is a fat burner for women that uses natural ingredients known to boost metabolism, maintain blood sugar levels, and reduce appetite. This weight loss pill is formulated exclusively for women looking for a practical way to burn fat and shed pounds to meet their health goals.

TrimTone is relatively new to the weight loss supplements market, but it has gained many satisfied customers in a short time. Its simple, 100% natural formula not only boosts metabolism but also helps suppress cravings. TrimTone comes with a 100-day money-back guarantee, so you can try it with confidence.

Results to Expect from TrimTone

  • Burns fat
  • Reduces appetite
  • Boost metabolism
  • 100% natural ingredients

How Does It Work?

TrimTone works by stimulating thermogenesis, which is the conversion of fat into energy. Several of its natural ingredients are known to boost your metabolic rate, so you'll be burning fat even when at rest.

Ingredients like green coffee have the extra benefit of helping to reduce how much fat and glucose is absorbed by the digestive system. Burning fat is great, but a weight loss supplement needs to help suppress appetite in order to be really effective. TrimTone contains glucomannan, a potent appetite suppressant that helps reduce cravings by making you feel full between meals.


  • Caffeine
  • Green coffee bean extract
  • Green tea extract
  • Grains of paradise
  • Glucomannan

TrimTone couldn't be easier to use—take one capsule per day before breakfast with a glass of water.

Who Is This Product For?

If your primary health goal is to burn body fat gradually over time, then TrimTone is the best weight loss pill for you. This weight loss supplement was made to help you lose weight by boosting your metabolism, so it's ideal for women who eat right but still struggle to lose those stubborn pounds.

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#4) Hourglass Fit: Most Effective for Appetite Suppression

hourglass fit

Hourglass Fit is the best weight loss pill for appetite suppression. Reducing calorie intake is an essential part of any weight loss program. But when cravings strike, it can be tough to stick to your diet. That's why ingredients that help you feel full are key to any effective weight loss pill. Hourglass Fit is an excellent weight loss pill for women looking for help with appetite suppression and reducing cravings. In addition, it’s a good fat burner, and it contains 5-HTP to provide a gentle, natural mood lift.

How Does It Work?

Hourglass Fit contains a huge 3g daily dose of glucomannan to make you feel less hungry. Other natural ingredients like chromium and zinc also help to reduce cravings.

Cayenne pepper and black pepper extract (piperine) help increase thermogenesis, kicking the body fat burning process into high gear. Hourglass Fit also contains B vitamins to help support your well-being—body and mind—so you can lose weight healthily.


  • Glucomannan
  • Chromium picolinate
  • Cayenne pepper extract
  • Piperine
  • Zinc
  • 5-HTP
  • Vitamin B2, B6, and B12

The recommended dose of Hourglass Fit is one capsule four times a day. As with any weight loss supplement that contains fiber, drink a glass of water with each dose.

Who Is This Product For?

Hourglass Fit is perfect for women who want help fighting the urge to snack between meals. It will reduce cravings to supplement your weight loss diet. Its potent but gentle formula of appetite suppressants and fat burners make it one of the top weight loss pills we reviewed.

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#5) Powher Cut: Best for Active Women


Powher Cut is a fat burner and appetite suppressant for women produced by the same company that manufactures LeanBean. It's a diet pill made with all-natural ingredients formulated specifically for women. There is no "proprietary blend" in Powher Cut; all of the ingredients contained in the supplement are clearly labeled on the bottle.

Manufactured to GMP standards in FDA-registered facilities, Powher Cut comes with a 90-day money-back guarantee. We think it's a weight loss pill worth checking out, especially if you already have an active lifestyle but need help controlling cravings.

How Does It Work?

Powher Cut supports natural weight loss by helping you feel full to reduce cravings. The glucomannan fiber absorbs a great deal of water and expands in your stomach, making you feel full. This makes it easier to maintain a reduced-calorie diet so you can lose weight.

The Powher Cut formula also contains nutrients that are essential to a healthy digestive system and metabolism, so your body can burn fat and lose weight. It includes a dose of caffeine just large enough to provide a performance boost and increase your metabolic rate without unpleasant side effects.


  • Konjac fiber (glucomannan)
  • Caffeine
  • Choline
  • Chromium
  • Magnesium
  • Iron
  • Selenium

Powher Cut recommends taking two capsules with a glass of water three times per day before each meal.

Who Is This Product For?

Many women spend long hours in the gym but can't get rid of their love handles or underarm fat. If this sounds like you, Powher Cut is here to help. This supplement will help reduce cravings, making it easier to stick to your diet after a gym session. It’s designed to help you shed those last few pounds and reveal your six-pack abs.

  • Clinically Studied Natural Ingredients That Work
  • Weight Loss Supplement Designed to Fire Up Your Shredding Goals
  • Supports Metabolism & Improves Endurance Capacity
  • 90-Day Money-Back Guarantee

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Factors to Consider When Buying Weight Loss Pills

The market for women’s weight loss pills continues to grow, and there is a bewildering array of products to choose from. Here are some things to keep in mind when searching for the most effective weight loss pills.


Ingredients are the most important thing to consider when evaluating a weight loss supplement. After all, a product's efficacy and safety are determined by its components, not its price or packaging.

Be sure you know all the ingredients before taking a weight loss supplement. If a manufacturer touts a "proprietary formula," it could be just a way for them to avoid disclosing all of their ingredients. Transparency is key, and knowledge is power, so make sure you know what's going into your body.

Of course, natural is always preferable, right? While that’s generally true, just because a supplement carries the label “all-natural" doesn't necessarily mean it is better for your health. For example, caffeine is natural, but too much of it can certainly harm you.

Even so, it's still a good idea to avoid synthetic ingredients, fillers, and artificial colors if possible. All-natural weight loss products are more likely to be a safe, healthy choice.


Dosage is important to consider. Depending on your daily routine and lifestyle, you may be fine with a weight loss pill that you take three or four times a day, or you might simply prefer to take one pill in the morning.

Dose timing is something to be aware of too. Weight loss pills with a high fiber content work most efficiently when taken before a meal. And if a pill has a lot of caffeine, it might interfere with your sleep if taken too late in the day.

Safety Side and Effects

The Food and Drug Administration does not regulate the claims that supplement manufacturers make for their weight loss products. So before starting a new diet or taking supplements, it's important to ask your doctor about the long-term health effects of weight loss pills. This is especially true if you are currently taking medication or are pregnant or breastfeeding.

Customer Reviews

While customer reviews aren't as reliable as clinical evidence, other users can help shape your opinion about a particular weight loss drug. Customer reviews can provide valuable insights into the benefits and drawbacks of specific weight loss pills as well as warn you of potential side effects.

Price and Guarantee

All the supplements we recommend offer some kind of money-back guarantee. Their price varies with the quality of ingredients and the number of doses in a bottle. Most companies charge around $40 to $70 for a one-month supply, and many offer "buy one, get one free" deals. Often, you can save money when buying enough for two or three months at a time.

Do Women Lose Weight Differently Than Men?

Women do indeed face different challenges than men do when it comes to losing weight. The reasons are mostly biological, though some could be behavioral. Muscles and metabolism play a large part.

Muscles burn more calories than fat, and because men have more muscle mass than women, they tend to find it easier to lose weight. Men generally have a faster metabolism than women as well.

It's possible that differences in the way women and men exercise could be a factor as well. Men tend toward heavy lifting exercises, which boost muscle and metabolic rate. Typically, women are more likely to work out with lighter weights and focus on cardiovascular exercise because they don't want to bulk up.

According to a 2009 study, ghrelin (the hormone that signals hunger) spikes after women work out, while leptin (which signals fullness) drops dramatically. Men don't experience these same hormone fluctuations, which may mean that they eat less after workouts.

Genetic makeup is also important. Your body is programmed to stay within a certain weight range, and it can be incredibly hard to go against that. Your body shape is genetic as well, so that may be another factor that makes weight loss more difficult.

Types of Diet Pills That Work for Women

Fat Burners

Your body's metabolism is the process of producing heat to burn calories and absorb nutrients. Many weight loss drugs include supplements to speed up your metabolism, thus burning more fat.

Caffeine is one of the most popular ingredients to stimulate fat burning. Other thermogenic, or heat-producing, substances include capsaicin, garcinia cambogia, raspberry ketone, and yohimbine.

Carb Blockers

Rather than getting rid of fat, carb blockers prevent your body from digesting complex carbohydrates. This occurrence is due to a group of compounds called alpha-amylase inhibitors, found in foods like beans and whole wheat flour.

These carb blockers tell your digestive system to ignore carb-heavy foods, so they pass through without contributing calories to your diet.

Appetite Suppressants

If you find yourself overeating because you feel empty, then an appetite suppressant could be a helpful weight loss option. Appetite suppressants work by making you feel full even when you're not. Caffeine is one of the most common ingredients used to limit hunger; it works by dulling the signals from hunger hormones.

Other common appetite suppressants include conjugated linoleic acid, and glucomannan. Glucomannan and other high-fiber ingredients work by expanding in your stomach to give you a feeling of fullness so you'll be less tempted to overeat.

Popular Ingredients in the Best Diet Pills for Women


Made from konjac root (aka elephant yam), glucomannan is a soluble dietary fiber found in many of the top weight loss supplements. In your stomach, this ingredient absorbs water and expands to make you feel full. As with all fiber supplements, you'll get the most benefit if you take it before a meal with a full glass of water.

Green Coffee Bean Extract

Green coffee bean extract comes from raw, unroasted coffee beans and contains chlorogenic acid that would otherwise be lost in the roasting process. Chlorogenic acid is thought to reduce the amount of glucose and fat your gut absorbs, which lowers insulin levels and improves your metabolism.

This popular weight loss supplement ingredient has other health benefits too. Some positives include improved blood pressure and healthier cholesterol levels. Green coffee is also a source of caffeine and therefore has thermogenic properties, increasing your metabolism so you burn calories faster, even at rest.

Garcinia Cambogia

Garcinia cambogia comes from an Indonesian tropical fruit called the Malabar tamarind. It is an appetite suppressant with thermogenic properties. Scientists say it may help lower blood sugar levels. The main active factor in Garcinia cambogia is hydroxycitric acid, which stimulates the body to burn fat for energy.

Green Tea Extract

The antioxidant benefits of green tea are well documented. It contains a gentle amount of caffeine, which is thermogenic and helps tamp down appetite. And it's also full of compounds that are believed by some to increase the levels of hormones that tell your cells to break down fat.

Some researchers also theorize that the catechins in green tea may reduce the absorption of carbohydrates, so your body may store fewer carbs as fat. With so many different benefits, it's no wonder green tea is one of the most popular ingredients in weight loss pills!

Conjugated Linoleic Acid (CLA)

CLA comes from grass-eating animals like deer and goats. Studies link CLA to increased fat burning and weight loss. It comes in a handful of varieties, but c9 t11 is the form most likely to be found in weight loss products.


Caffeine is one of the most common ingredients in weight loss pills, and for good reason. It has several proven benefits for all facets of life.

A single 100mg dose (about as much as an 8 ounce cup of coffee) can increase your resting metabolic rate by 3–4%. Speeding up your metabolism burns calories, and caffeine has the bonus effect of promoting the breakdown of fat.

Additionally, we all know that exercise is an important part of any weight loss plan. Caffeine provides an energy boost that can increase exercise performance by up to 11%.

It's a mood lifter too, and it suppresses feelings of hunger. Basically, caffeine is the weight loss bomb!

Raspberry Ketones

A raspberry ketone is a molecule naturally found in blackberries, cranberries, and other fruits. Scientists have discovered that raspberry ketones help mice break down fat, control blood sugar levels, and regulate their metabolism.

Prescription Weight Loss Pills to Consider


Orlistat is a prescription drug in most of the world, but it is sold over the counter as Alli in the US and UK. It is intended to treat obesity in conjunction with a doctor-supervised low-calorie diet. Orlistat decreases the amount of fat that people can absorb after eating.

In your intestines, an enzyme called lipase is responsible for breaking down fat. Orlistat blocks the action of lipase so your body can't store the fat, passing it on through the digestive system instead. Orlistat also reduces blood pressure and appears to prevent the onset of type 2 diabetes. Side effects may include soft stools and gassiness.


Contrave is a combination of two established medicines—naltrexone and bupropion. Naltrexone is used for treating addiction, and bupropion is an effective antidepressant. Together, they can eliminate hunger pangs, uplift mood, and control cravings.

In studies, this prescription weight loss drug was shown to double the number of test subjects who achieved their weight loss goals compared to a placebo. Potential side effects include dizziness, nausea, and constipation.


As you might guess from the name, Phentermine is a type of amphetamine. It is a CNS stimulant that elevates heart rate and decreases appetite. It is a commonly used weight loss drug for people with high cholesterol or diabetes.

One downside of Phentermine is the tendency for people to become used to it. The beneficial effects can be reduced after just a few weeks. Other potential side effects include headaches, dizziness, chest pain, and difficulty breathing.


Belviq reduces appetite by activating a type of serotonin receptor in the section of the brain that controls appetite, so you feel full even after a small meal. It is used for the long-term treatment of obesity.

While Belviq can help you lose weight, it does nothing to treat the underlying issues that caused weight gain in the first place. Also, this prescription weight loss pill won't improve cholesterol levels, diabetes, or heart disease. Some potential side effects can include nausea, sore throat, irregular heartbeat, and seizures.


Xenical is the prescription-only version of Alli (Orlistat). Both work to prevent the body from absorbing dietary fat, but Xenical delivers a higher dose. This prescription weight loss drug works best in conjunction with a low-calorie diet.

In a study from the Baylor College of Medicine, the combination of Xenical and a low-calorie diet significantly lowered body mass for most participants. Xenical causes the undigested fats to be eliminated within a day or two of their consumption. Potential side effects can include abdominal pain, soft stools, and low vitamin D levels.

Can You Buy Weight Loss Supplements for Women Over the Counter?

You can buy fat burners and weight loss pills over the counter, but the quality varies quite a bit. Some OTC diet pills aren't backed by any clinical tests for efficacy and safety.

Also, keep in mind that the FDA regulates only non-prescription weight loss drugs. Manufacturers of weight loss supplements don't have their claims validated by the FDA and are trusted to regulate themselves. You never know what side effects they might cause.

To be sure you're getting the safest and most effective weight loss supplements, you're better off choosing one of the products we have reviewed. It's also a good idea to purchase directly from the manufacturer whenever possible so you can be sure the product you receive is genuine and fresh.

Do Women's Weight Loss Pills Have Any Side Effects?

Natural weight loss pills don't tend to have many side effects, and the few side effects that occur are relatively mild. Typically, it depends on the formulation and functionality of the pill.

For example, diet pills and supplements that contain stimulants may cause insomnia and increase blood pressure and heart rate. If you're taking a product that includes a stimulant, avoid long-term side effects by using it for three months or less.

Also, fat blockers such as Orlistat may cause soft stools and gassiness, since they affect your digestive system.

At the end of the day, each person is unique and will experience side effects differently. A particular diet pill may produce negative side effects for one woman, but another woman taking the same dose may not notice any side effects at all.

How to Get the Best Results with Female Weight Loss Pills

Any popular weight loss pill for women will work best in conjunction with a healthy, low-fat diet and regular exercise. In fact, most are designed specifically with that combination in mind. These pills are meant to support a lifestyle that includes eating less and having more energy to exercise, so for best results, you will need to do your part.

You may still see some effects if you take a diet pill on its own, but the most effective way to achieve your ideal body weight is with a regular exercise regimen and a lifestyle focus on health.

Final Verdict–Are Diet Pills Right for You?

Diet pills are right for many women who need to lose excess pounds, suppress cravings, boost metabolism, reduce fat, and get more energy.

If you've been exercising and watching what you eat, you expect to see results. However, many people struggle to reach their target body weight even when doing all the right things. If this sounds like you, a weight loss supplement may provide the extra help you need.

Also, if you struggle to diet and exercise, a diet pill can give you the extra boost you need to take that first step into the gym.

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*This article is provided by an advertiser. Statements made are not meant to offer medical advice nor to diagnose any condition. Any studies cited here may be preliminary, and may or may not be peer reviewed, and may or may not have sufficient participants to be statistically relevant. Anecdotal accounts should not be taken as scientific results. Products discussed in this article are not designed to diagnose, treat, prevent, or cure any disease. The FDA does not evaluate dietary supplements. Consult your doctor about possible interactions, allergies, and if you are considering using a natural and/or dietary supplements for any condition. Individual results will vary.


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