Flow or discharge of sebum

Flow or discharge of sebum DEFAULT

6 Integumentary System

  • Identify the anatomy of the integumentary system
  • Describe the main functions of the integumentary system
  • Spell the integumentary system medical terms and use correct abbreviations
  • Identify the medical specialties associated with the integumentary system
  • Explore common diseases, disorders, and procedures related to the integumentary system

Integumentary System Word Parts

Click on prefixes, combining forms, and suffixes to reveal a list of word parts to memorize for the Integumentary System.

Introduction to the Integumentary System

The integumentary system refers to the skin and its accessory structures. In the adult human body, the skin makes up about 16 percent of body weight and covers an area of 1.5 to 2 m2.

In fact, the skin and accessory structures are the largest organ system in the human body. The skin protects your inner organs and it is in need of daily care and protection to maintain its health.

Watch this video:

Practice integumentary system medical terms.

Anatomy (Structures) of the Integumentary System

The skin and its accessory structures make up the integumentary system, which provides the body with overall protection. The skin is made of multiple layers of cells and tissues, which are held to underlying structures by connective tissue. The deeper layer of skin is well . It also has numerous sensory, and and nerve fibers ensuring communication to and from the brain.

The skin is composed of two main layers:

  1. The
  2. The
    1. Beneath the dermis lies the
Layers of the skin. Image description available.
  • On the diagram above find the two layers of the skin; epidermis and dermis.
  • The literal breakdown for hypodermis is below the dermis. On the diagram above where can you locate it?
  • Can you find a hair follicle, hair root and hair shaft?
  • Keep reading to find out what the arrector pili muscle does when you are frightened.


The is composed of keratinized, stratified squamous epithelium. It is made of four or five layers of epithelial cells, depending on its location in the body. It is .

  • Thin skin has four layers of cells. From deep to superficial, these layers are the , stratum spinosum, stratum granulosum, and stratum corneum. Most of the skin can be classified as thin skin.
  • Thick skin is found only on the palms of the hands and the soles of the feet. It has a fifth layer, called the stratum lucidum, located between the stratum corneum and the stratum granulosum (see Figure 6.2).
Thin skin versus thick skin in photographs. Image description available.

The cells in all of the layers except the stratum basale are called .  Keratin is an intracellular fibrous protein that gives hair, nails, and skin their hardness and water-resistant properties. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from the deeper layers (see Figure 6.3).

The epidermis. Image description available.


The dermis contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers (papillary layer and reticular layer) of connective tissue that compose an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts (see Figure 6.4).
Layers of the dermis. Image description available.

Papillary Layer

The papillary layer is made of loose, areolar connective tissue, which means the collagen and elastin fibers of this layer form a loose mesh. This superficial layer of the dermis projects into the stratum basale of the epidermis to form finger-like dermal papillae (see Figure 6.4). Within the papillary layer are fibroblasts, a small number , and an abundance of small blood vessels. In addition, the papillary layer contains , that help fight bacteria or other infections that have breached the skin. This layer also contains lymphatic capillaries, nerve fibers, and  .

Reticular Layer

Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective tissue. This layer is well and has a rich sensory and nerve supply. The reticular layer appears due to a tight meshwork of fibers. Elastin fibers provide some elasticity to the skin, enabling movement. Collagen fibers provide structure and tensile strength, with strands of collagen extending into both the papillary layer and the hypodermis. In addition, collagen binds water to keep the skin hydrated. Collagen injections and Retin-A creams help restore skin turgor by either introducing collagen externally or stimulating blood flow and repair of the dermis, respectively.


The serves to connect the skin to the underlying of the bones and muscles. It is not strictly a part of the skin, although the border between the and can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and tissue, which functions as a mode of fat storage and provides insulation and cushioning for the integument.

Practice labeling the layers of the skin.

Physiology (Function) of the Integumentary System

The skin and accessory structures perform a variety of essential functions, such as protecting the body from invasion by microorganisms, chemicals, and other environmental factors; preventing dehydration; acting as a sensory organ; modulating body temperature and electrolyte balance; and synthesizing vitamin D. The underlying hypodermis has important roles in storing fats, forming a “cushion” over underlying structures, and providing insulation from cold temperatures.


The skin protects the body from wind, water, and UV sunlight. It acts as a protective barrier against water loss and it also is the first line of defense against abrasive activity such as grit, microbes, or harmful chemicals. Sweat excreted from sweat glands deters microbes from over-colonizing the skin surface by generating dermicidin, which has antibiotic properties.

Sensory Function

The skin acts as a sense organ because the epidermis, dermis, and the hypodermis contain specialized sensory nerve structures that detect touch, surface temperature, and pain. These receptors are more concentrated on the tips of the fingers, which are most sensitive to touch, especially the , which responds to light touch, and the , which responds to vibration. Merkel cells, seen scattered in the stratum basale, are also touch receptors. In addition to these specialized receptors, there are sensory nerves connected to each hair follicle, pain and temperature receptors scattered throughout the skin, and motor nerves innervate the arrector pili muscles and glands. This rich innervation helps us sense our environment and react accordingly,


The integumentary system helps regulate body temperature through its tight association with the . The sympathetic nervous system is continuously monitoring body temperature and initiating appropriate motor responses.

  1.  When the body becomes warm sweat glands, accessory structures to the skin, secrete water, salt, and other substances to cool the body.
    1. Even when the body does not appear to be noticeably sweating, approximately 500 mL of sweat are secreted a day.
  2. If the body becomes excessively warm due to high temperatures, vigorous activity, or a combination of the two, sweat glands will be stimulated by the sympathetic nervous system to produce large amounts of sweat.
    1. When the sweat evaporates from the skin surface, the body is cooled as body heat is dissipated.
    2. In addition to sweating, arterioles in the dermis dilate so that excess heat carried by the blood can dissipate through the skin and into the surrounding environment (Figure 2b).
    3. This accounts for the skin redness that many people experience when exercising.
  3. When body temperatures drop, the arterioles constrict to minimize heat loss, particularly in the ends of the digits and tip of the nose.
    1. This reduced circulation can result in the skin taking on a whitish hue.
    2. Although the temperature of the skin drops as a result, passive heat loss is prevented, and internal organs and structures remain warm.
    3. If the temperature of the skin drops too much (such as environmental temperatures below freezing), the conservation of body core heat can result .
Thermoregulation. Image description available.

Can you describe the thermoregulation process between the integumentary system and the sympathetic system?

  • When body temperature is too warm.
  • When body temperature is too cold.

Vitamin D Synthesis

The epidermal layer of human skin synthesizes Vitamin D when exposed to UV radiation. In the presence of sunlight, a form of Vitamin D3 called cholecalciferol is synthesized from a derivative of the steroid cholesterol in the skin. The liver converts cholecalciferol to calcidiol, which is then converted to calcitriol (the active chemical form of the vitamin) in the kidneys.

  • Vitamin D is essential for normal absorption of calcium and phosphorous, which are required for healthy bones.
  • The absence of sun exposure can lead to a lack of vitamin D in the body, in children this can cause .  Vitamin D deficiency in elderly individuals may lead to .
  • In present day society, Vitamin D is added as a supplement to many foods, including milk and orange juice, compensating for the need for sun exposure. In addition to its essential role in bone health, Vitamin D is essential for general immunity against bacterial, viral, and fungal infections.

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Accessory structures of the skin include hair, nails, sweat glands, and sebaceous glands. These structures embryologically originate from the epidermis and can extend down through the dermis into the .


Hair is a keratinous filament growing out of the . It is primarily made of dead, keratinized cells. Strands of hair originate in an epidermal penetration of the dermis called the hair follicle. The hair shaft is the part of the hair not anchored to the follicle, and much of this is exposed at the skin’s surface. The rest of the hair, which is anchored in the follicle, lies below the surface of the skin and is referred to as the hair root. The hair root ends deep in the dermis at the hair bulb, and includes a layer of mitotically active basal cells called the hair matrix. The hair bulb surrounds the hair papilla, which is made of connective tissue and contains blood capillaries and nerve endings from the dermis (see Figure 6.6).

Cross section of a hair follicle. Image description available.

Hair Function

Hair serves a variety of functions, including protection, sensory input, thermoregulation, and communication. For example:

  • Hair on the head protects the skull from the sun.
  • Hair in the nose and ears, and around the eyes (eyelashes) defends the body by trapping and excluding dust particles that may contain allergens and microbes.
  • Hair of the eyebrows prevents sweat and other particles from dripping into and bothering the eyes.

Hair also has a sensoryfunction due to sensory innervation by a hair root plexus surrounding the base of each hair follicle. Hair is extremely sensitive to air movement or other disturbances in the environment, much more so than the skin surface. This feature is also useful for the detection of the presence of insects or other potentially damaging substances on the skin surface.

Each hair root is connected to a smooth muscle called the arrector pili that contracts in response to nerve signals from the sympathetic nervous system, making the external hair shaft “stand up.” The primary purpose for this is to trap a layer of air to add insulation. This is visible in humans as goose bumps and even more obvious in animals, such as when a frightened cat raises its fur. Of course, this is much more obvious in organisms with a heavier coat than most humans, such as dogs and cats.

Hair Growth, Loss and Colour

Hair grows and is eventually shed and replaced by new hair.  Hair typically grows at the rate of 0.3 mm per day. On average, 50 hairs are lost and replaced per day. Hair loss occurs if there is more hair shed than what is replaced and can happen due to hormonal or dietary changes. Hair loss can also result from the aging process, or the influence of hormones. Similar to the skin, hair gets its colour from the pigment melanin, produced by in the hair papilla. Different hair color results from differences in the type of melanin. As a person ages, the melanin production decreases, and hair tends to lose its color and becomes gray and/or white.


The nail bed is a specialized structure of the epidermis that is found at the tips of our fingers and toes. The nail body is formed on the nail bed, and protects the tips of our fingers and toes as they are the farthest extremities and the parts of the body that experience the maximum mechanical stress (see Figure 6.7). The nail body forms a back-support for picking up small objects with the fingers. The nail body is composed of densely packed dead .

The epidermis in this part of the body has evolved a specialized structure upon which nails can form. The nail body forms at the nail root, which has a matrix of proliferating cells from the stratum basale that enables the nail to grow continuously. The lateral nail fold overlaps the nail on the sides, helping to anchor the nail body. The nail fold that meets the proximal end of the nail body forms the nail cuticle, also called the eponychium.

The nail bed is rich in blood vessels, making it appear pink, except at the base, where a thick layer of epithelium over the nail matrix forms a crescent-shaped region called the lunula (the “little moon”). The area beneath the free edge of the nail, furthest from the cuticle, is called the hyponychium. It consists of a thickened layer of stratum corneum.

Anatomy of the fingernail. Image description available.

Sweat Glands

Sudoriferous Glands

When the body becomes warm, sudoriferous glands produce sweat to cool the body. Sweat glands develop from epidermal projections into the dermis and are classified as merocrine glands; that is, the secretions are excreted by through a duct without affecting the cells of the gland. There are two types of sweat glands, each secreting slightly different products.

An eccrine sweatgland is type of gland that produces a hypotonic sweat for thermoregulation as described previously. These glands are found all over the skin’s surface, but are especially abundant on the palms of the hand, the soles of the feet, and the forehead (Figure 6.8). They are coiled glands lying deep in the dermis, with the duct rising up to a pore on the skin surface, where the sweat is released. This type of sweat, released by , is hypotonic and composed mostly of water, with some salt, antibodies, traces of metabolic waste, and dermicidin, an antimicrobial peptide. Eccrine glands are a primary component of thermoregulation in humans and thus help to maintain .

Eccrine sweat gland. Image description available.

An apocrine sweat gland is usually associated with hair follicles in densely hairy areas, such as armpits and genital regions. Apocrine sweat glands are larger than eccrine sweat glands and lie deeper in the dermis, sometimes even reaching the hypodermis, with the duct normally emptying into the hair follicle. In addition to water and salts, apocrine sweat includes organic compounds that make the sweat thicker and subject to bacterial decomposition and subsequent smell. The release of this sweat is under both nervous and hormonal control, and plays a role in the poorly understood human pheromone response. Most commercial antiperspirants use an aluminum-based compound as their primary active ingredient to stop sweat. When the antiperspirant enters the sweat gland duct, the aluminum-based compounds precipitate due to a change in pH and form a physical block in the duct, which prevents sweat from coming out of the pore.

Sebaceous Glands

A sebaceous gland is a type of oil gland that is found all over the body and helps to lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable. The fatty acids of sebum also have antibacterial properties, and prevent water loss from the skin in low-humidity environments. The secretion of sebum is stimulated by hormones, many of which do not become active until puberty. Thus, sebaceous glands are relatively inactive during childhood.

Words not Easily Broken into Word Parts

Common Integumentary System Abbreviations

Many terms and phrases related to the integumentary system are abbreviated.  Learn these common abbreviations by expanding the list below.

Changes Due to Aging

All systems in the body accumulate subtle and some not-so-subtle changes as a person ages. Among these changes are reductions in cell division, metabolic activity, blood circulation, hormonal levels, and muscle strength (see Figure 6.9). In the skin, these changes are reflected in decreased mitosis in the stratum basale, leading to a thinner epidermis. The dermis, which is responsible for the elasticity and resilience of the skin, exhibits a reduced ability to regenerate, which leads to slower wound healing. The hypodermis, with its fat stores, loses structure due to the reduction and redistribution of fat, which in turn contributes to the thinning and sagging of skin.

Young and older woman on the telephone. Image description available.

The accessory structures also have lowered activity, generating thinner hair and nails, and reduced amounts of sebum and sweat. A reduced sweating ability can cause some elderly to be intolerant to extreme heat. Other cells in the skin, such as and cells, also become less active, leading to a paler skin tone and lowered immunity. Wrinkling of the skin occurs due to breakdown of its structure, which results from decreased collagen and elastin production in the dermis, weakening of muscles lying under the skin, and the inability of the skin to retain adequate moisture.

Disease and Disorders

The integumentary system is susceptible to a variety of diseases, disorders, and injuries. These range from annoying but relatively benign bacterial or fungal infections that are categorized as disorders, to skin cancer and severe burns, which can be fatal. In this section, you will learn several of the most common skin conditions.

One of the most talked about diseases is skin . Most cancers are identified by the organ or tissue in which the cancer originates. One common form of cancer is skin cancer.

In general, cancers result from an accumulation of DNA mutations. These mutations can result in cell populations that do not die when they should and uncontrolled cell proliferation that leads to tumors. Although many tumors are , some . Cancers are characterized by their ability to metastasize.

Sun Damage

It requires about 10 days after initial sun exposure for melanin synthesis to peak, which is why pale-skinned individuals tend to suffer sunburns of the epidermis initially. Dark-skinned individuals can also get sunburns, but are more protected than are pale-skinned individuals. Too much sun exposure can eventually lead to wrinkling due to the destruction of the cellular structure of the skin, and in severe cases, can cause sufficient DNA damage to result in skin cancer. When there is an irregular accumulation of melanocytes in the skin, freckles appear. Moles are larger masses of melanocytes, and although most are benign, they should be monitored for changes that might indicate the presence of cancer (see Figure 6.10).

Five photos of moles. Image description available.

Basal Cell Carcinoma (BCC)

Image of basal cell carcinoma

Basal cell carcinoma is a form of cancer that affects the mitotically active stem cells in the stratum basale of the epidermis. It is the most common of all cancers that occur in the United States and is frequently found on the head, neck, arms, and back, which are are as that are most susceptible to long-term sun exposure. Although UV rays are the main culprit, exposure to other agents, such as radiation and arsenic, can also lead to this type of cancer. Wounds on the skin due to open sores, tattoos, burns, etc. may be predisposing factors. Basal cell carcinomas start in the stratum basale and usually spread along this boundary. At some point, they begin to grow toward the surface and become an uneven patch, bump, growth, or scar on the skin surface (see Figure 6.11). Like most cancers, basal cell carcinomas respond best to treatment when caught early. Treatment options include surgery, freezing (cryosurgery), and topical ointments.

Squamous Cell Carcinoma (SCC)

Image of squamous cell carcinoma on a person's nose

Squamous cell carcinoma is a cancer that affects the keratinocytes of the stratum spinosum and presents as lesions commonly found on the scalp, ears, and hands (see Figure 6.12). It is the second most common skin cancer. The American Cancer Society reports that two of 10 skin cancers are squamous cell carcinomas, and it is more aggressive than basal cell carcinoma. If not removed, these carcinomas can . Surgery and radiation are used to cure squamous cell carcinoma.


Image of a melanoma

A melanoma is a cancer characterized by the uncontrolled growth of melanocytes, the pigment-producing cells in the epidermis. Typically, a melanoma develops from a mole. It is the most fatal of all skin cancers, as it is highly metastatic and can be difficult to detect before it has spread to other organs. Melanomas usually appear as asymmetrical brown and black patches with uneven borders and a raised surface (see Figure 6.13). Treatment typically involves surgical excision and immunotherapy.

ABCDE for Early Diagnosis

Doctors often give their patients the following ABCDE mnemonic to help with the diagnosis of early-stage melanoma. If you observe a mole on your body displaying these signs, consult a doctor.

Asymmetry – the two sides are not symmetrical
Borders – the edges are irregular in shape
Color – the color is varied shades of brown or black
Diameter – it is larger than 6 mm (0.24 in)
Evolving – its shape has changed

Some specialists cite the following additional signs for the most serious form, nodular melanoma:

Elevated – it is raised on the skin surface
Firm – it feels hard to the touch
Growing – it is getting larger


Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. This is primarily due to the inability of melanocytes to produce melanin. Individuals with albinism tend to appear white or very pale due to the lack of melanin in their skin and hair. Recall that melanin helps protect the skin from the harmful effects of UV radiation. Individuals with albinism tend to need more protection from UV radiation, as they are more prone to sunburns and skin cancer. They also tend to be more sensitive to light and have vision problems due to the lack of pigmentation on the retinal wall (Betts, et al., 2013)

Treatment of this disorder usually involves addressing the symptoms, such as limiting UV light exposure to the skin and eyes. In vitiligo, the melanocytes in certain areas lose their ability to produce melanin, possibly due to an autoimmune reaction. This leads to a loss of color in patches (see Figure 6.14). Neither albinism nor vitiligo directly affects the lifespan of an individual (Betts, et al., 2013)

This photo shows the back of a man’s neck. There is a large, discolored patch of skin at the base of his hairline. The discolored area extends over the ears onto the cheeks, toward the front of the face. The man’s head and facial hair are mostly gray, but white patches of hair are seen above the discolored skin.

Changes in Skin Colouration

Other changes in the appearance of skin colouration can be indicative of diseases associated with other body systems.

  • Liver disease or liver cancer can cause the accumulation of bile and the yellow pigment bilirubin, leading to the skin appearing yellow or .
  • Tumors of the pituitary gland can result in the secretion of large amounts of melanocyte-stimulating hormone (MSH), which results in a darkening of the skin.
  • Addison’s disease can stimulate the release of excess amounts of adrenocorticotropic hormone (ACTH), which can give the skin a deep bronze color
  • A sudden drop in oxygenation can affect skin color, causing the skin to initially turn ashen (white).
  • A prolonged reduction in oxygen levels, dark red deoxyhemoglobin becomes dominant in the blood, making the skin appear blue, a condition referred to as . This happens when the oxygen supply is restricted, as when someone is experiencing difficulty in breathing because of asthma or a heart attack. However, in these cases the effect on skin color has nothing do with the skin’s pigmentation (Betts, et al., 2013)

Skin Disorders

Two common skin disorders are eczema and acne. Eczema is an inflammatory condition and occurs in individuals of all ages. Acne involves the clogging of pores, which can lead to infection and inflammation, and is often seen in adolescents. Other disorders, include seborrheic dermatitis (on the scalp), psoriasis, fungal infections, cold sores, impetigo, scabies, hives, and warts (Betts, et al., 2013).


Person with eczema on their forearms.

Eczema is an allergic reaction that manifests as dry, itchy patches of skin that resemble rashes (see Figure 6.15). It may be accompanied by swelling of the skin, flaking, and in severe cases, bleeding. Symptoms are usually managed with moisturizers, corticosteroid creams, and immunosuppressants (Betts, et al., 2013).


The three stages of acne plugged follicle, mild inflammation and marked inflammation

Acne is a skin disturbance that typically occurs on areas of the skin that are rich in sebaceous glands (face and back). It is most common along with the onset of puberty due to associated hormonal changes, but can also occur in infants and continue into adulthood. Hormones, such as androgens, stimulate the release of sebum. An overproduction and accumulation of sebum along with keratin can block hair follicles. This plug is initially white. The sebum, when oxidized by exposure to air, turns black. Acne results from infection by acne-causing bacteria (Propionibacterium and Staphylococcus), which can lead to redness and potential scarring due to the natural wound healing process (see Figure 6.16) (Betts, et al., 2013).


Tinea or dermatophytosis is often referred to as ringworm. Ringworm presents as a circular rash that is itchy and red and can be found on various parts of the body. It is referred to by the location that it is found:

    • Tinea Pedis – feet or commonly referred to as athlete’s feet
    • Tinea Capitis – scalp
    • Tinea barbae – beard
    • Tinea manuum – hands
    • Tinea unguium – Toenails and fingernails also called onychomycosis
    • Tinea corporis – Body parts such as arms and legs (Center for Disease Control and Prevention, 2018a)

To learn more about ringworm, visit the Center for Disease Control and Prevention’s web page on fungal infections.


Psoriasis is a chronic autoimmune disorder that results in patches of thick red skin with the appearance of silvery scales. These patches can be found on elbows, knees, scalp, low back, face, feet, fingernails, toenails and even the mouth. Psoriasis can be confused with other skin disease so a dermatologist is the best physician to diagnosis psoriasis. Treatments may include creams, ointments, ultraviolet light therapy and medication (Center for Disease Control and Prevention, 2018).  To learn more, visit the Center for Disease Control and Prevention’s web page on psoriasis.


Because the skin is the part of our bodies that meets the world most directly, it is especially vulnerable to injury. Injuries include burns, wounds, as well as scars and calluses. They can be caused by sharp objects, heat, or excessive pressure or friction to the skin (Betts, et al., 2013).

Skin injuries set off a healing process that occurs in several overlapping stages.

  • The first step to repairing damaged skin is the formation of a blood clot that helps stop the flow of blood and scabs over with time. Many different types of cells are involved in wound repair, especially if the surface area that needs repair is extensive.
  • Before the basal stem cells of the stratum basale can recreate the epidermis, fibroblasts mobilize and divide rapidly to repair the damaged tissue by collagen deposition, forming granulation tissue.
  • Blood capillaries follow the fibroblasts and help increase blood circulation and oxygen supply to the area.
  • Immune cells, such as macrophages, roam the area and engulf any foreign matter to reduce the chance of infection (Betts, et al., 2013).


A burn results when the skin is damaged by intense heat, radiation, electricity, or chemicals. The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset , as well as nutrients that enable the body to repair tissues and replace lost proteins. Another serious threat to the lives of burn patients is . Burned skin is extremely susceptible to bacteria and other , due to the loss of protection by intact layers of skin (Betts, et al., 2013).

Burn Classification

Burns are sometimes measured in terms of the size of the total surface area affected. This is referred to as the rule of nines, which associates specific anatomical areas with a percentage that is a factor of nine (see Figure 6.17) (Betts, et al., 2013).

Calculating the size of a burn. Image description available.

Burns are also classified by the degree of their severity.

  • A first-degree burn is a superficial burn that affects only the epidermis. Although the skin may be painful and swollen, these burns typically heal on their own within a few days. Mild sunburn fits into the category of a first-degree burn.
  • A second-degree burn goes deeper and affects both the epidermis and a portion of the dermis. These burns result in swelling and a painful blistering of the skin. It is important to keep the burn site clean and sterile to prevent infection. If this is done, the burn will heal within several weeks.
  • A third-degree burn fully extends into the epidermis and dermis, destroying the tissue and affecting the nerve endings and sensory function. These are serious burns that may appear white, red, or black; they require medical attention and will heal slowly without it.
  • A fourth-degree burn is even more severe, affecting the underlying muscle and bone.

Oddly, third and fourth-degree burns are usually not as painful because the nerve endings themselves are damaged. Full-thickness burns cannot be repaired by the body, because the local tissues used for repair are damaged and require , or amputation in severe cases, followed by grafting of the skin from an unaffected part of the body, or from skin grown in tissue culture for grafting purposes. Skin grafts are required when the damage from trauma or infection cannot be closed with sutures or staples (Betts et al., 2013).

Scars and Keloids

Most cuts or wounds, with the exception of ones that only scratch the epidermis, lead to formation. Scarring occurs in cases in which there is repair of skin damage, but the skin fails to regenerate the original skin structure. Fibroblasts generate scar tissue in the form of collagen, and the bulk of repair is due to the basket-weave pattern generated by collagen fibers and does not result in regeneration of the typical cellular structure of skin. Instead, the tissue is fibrous in nature and does not allow for the regeneration of accessory structures, such as hair follicles, sweat glands, or sebaceous glands (Betts, et al., 2013).

Sometimes, there is an overproduction of scar tissue, because the process of collagen formation does not stop when the wound is healed; this results in a . In contrast, scars that result from acne and chickenpox have a sunken appearance and are called atrophic scars (Betts, et al., 2013)

Scarring of skin after wound healing is a natural process and does not need to be treated further. Application of mineral oil and lotions may reduce the formation of scar tissue. However, modern cosmetic procedures, such as dermabrasion, laser treatments, and filler injections have been invented as remedies for severe scarring. All of these procedures try to reorganize the structure of the epidermis and underlying collagen tissue to make it look more natural (Betts, et al., 2013).

Bedsores and Stretch Marks

Skin and its underlying tissue can be affected by excessive pressure. One example of this is called a bedsore. Bedsores, also called decubitus ulcers, are caused by constant, long-term, unrelieved pressure on certain body parts that are bony, reducing blood flow to the area and leading to . Bedsores are most common in elderly patients who have debilitating conditions that cause them to be immobile. Most hospitals and long-term care facilities have the practice of turning the patients every few hours to prevent the incidence of bedsores. If left untreated bedsores can be fatal if they become infected (Betts, et al., 2013)

The skin can also be affected by pressure associated with rapid growth. A stretch mark results when the dermis is stretched beyond its limits of elasticity, as the skin stretches to accommodate the excess pressure. Stretch marks usually accompany rapid weight gain during puberty and pregnancy. They initially have a reddish hue, but lighten over time. Other than for cosmetic reasons, treatment of stretch marks is not required. They occur most commonly over the hips and abdomen (Betts, et al., 2013).


When you wear shoes that do not fit well and are a constant source of abrasion on your toes, you tend to form a callus at the point of contact. This occurs because the basal stem cells in the stratum basale are triggered to divide more often to increase the thickness of the skin at the point of abrasion to protect the rest of the body from further damage. This is an example of a minor or local injury, and the skin manages to react and treat the problem independent of the rest of the body. Calluses can also form on your fingers if they are subject to constant mechanical stress, such as long periods of writing, playing string instruments, or video games. A corn is a specialized form of callus. Corns form from abrasions on the skin that result from an elliptical-type motion (Betts, et al., 2013).

Medical Terms in Context

Medical Specialties and Procedures Related to the Integumentary System

A dermatologist is a medical doctor with specialized training in treating diseases, disorders and injuries related to the integumentary system and its accessory structures. There are many subspecialties such as cosmetic dermatology, and pediatric dermatology. To learn more visit the Dermatology and Subspecialties section of the Canadian Dermatology Association website.

Dermatologists can be specially trained to perform a procedure called Mohs surgery. Mohs surgery skin cancers in thin layers until all cancer is removed from the tissue (Mayo Clinic Staff, 2017).

Integumentary System Vocabulary


Fat cells.

Adipose tissue

Fat tissue.

Autonomic nerve fibers

Unconsciously regulates communication to and from the brain.


Without blood vessels.


Noncancerous, harmless.


A process where abnormal cells in the body divide uncontrollably.


Abnormal condition of blue (bluish colour, lips and nail beds). Typically caused by low oxygenation.


Excision of damaged tissue or foreign object.


Loss of fluids/water is greater than what is taken in.


Pertaining to dermatology.


Study of diseases of the skin.


The layer of skin that is made of dense, irregular connective tissue that houses blood vessels, hair follicles, sweat glands, and other structures.


Outer layer of skin, made of closely packed epithelial cells.


Remove by cutting out.


Active transport of molecules out of the cell.


Fibrous tissue.


Conservation of core body heat results in the skin actually freezing.


Literally means below the dermis. The layer of skin below the dermis that is composed mainly of loose connective and fatty tissues.


Invasion by disease-causing organisms.


Pertaining to within the vein.




Formation of a raised or hypertrophic scar.


Cells that manufacture and store the protein keratin.

Meissner corpuscle

Tactile corpuscle that responds to light and touch, touch receptor.

Meissner corpuscles

Tactile corpuscle that responds to light and touch, touch receptors.


Specialized cells that produce melanin which is a dark pigment responsible for colouration of skin and hair.


Production of cells that can mobilize and establish tumors in other organs of the body.


Tissue death.


Softening of the bones.

Pacinian corpuscle

Lamellated corpuscle that responds to vibration.


Disease-causing agents.


Cells that engulf and absorb bacteria and cell particles.


Net like.


A painful condition in children where bones are misshapen due to a lack of calcium, causing bow leggedness.


Collagen-rich skin formed after the process of wound healing that differs from normal skin.

Stratum Basale

Deepest layer of the epidermal.

Sympathetic nerve fibers

Flight or fight response determines communication to and from the brain.

Sympathetic Nervous System

Responsible for fight or flight responses.


Has numerous blood vessels.

Test Yourself


Centers for Disease Control and Prevention. (2018, October 25). Psoriasis. Centers for Disease Control and Prevention: Fungal Diseases. https://www.cdc.gov/psoriasis/

Centers for Disease Control and Prevention. (2018a, August 6). Ringworm.  Centers for Disease Control and Prevention: Fungal Diseases.  https://www.cdc.gov/fungal/diseases/ringworm/definition.html

CrashCourse. (2015, January 6). The Integumentary system, part 1 – skin deep: Crash Course A&P #6 [Video]. YouTube. https://youtu.be/Orumw-PyNjw

CrashCourse. (2015, February 16). The Integumentary system, part 2 – skin deeper: Crash Course A&P #7 [Video]. YouTube. https://youtu.be/EN-x-zXXVwQ

Mayo Clinic Staff. (2017, September 6). Mohs surgery. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/mohs-surgery/about/pac-20385222#:~:text=Mohs%20surgery%20is%20a%20precise,known%20as%20Mohs%20micrographic%20surgery.

Image Descriptions

Figure 6.1 image description: This illustration shows a cross section of skin tissue. The outermost layer is called the epidermis, and occupies one fifth of the cross section. Several hairs are emerging from the surface. The epidermis dives around one of the hairs, forming a follicle. The middle layer is called the dermis, which occupies four fifths of the cross section. The dermis contains an erector pilli muscle connected to one of the follicles. The dermis also contains an eccrine sweat gland, composed of a bunch of tubules. One tubule travels up from the bunch, through the epidermis, opening onto the surface a pore. There are two string-like nerves travelling vertically through the dermis. The right nerve is attached to a Pacinian corpuscle, which is a yellow structure consisting of concentric ovals similar to an onion. The lowest level of the skin, the hypodermis, contains fatty tissue, arteries, and veins. Blood vessels travel from the hypodermis and connect to hair follicles and erector pilli muscle in the dermis. [Return to Figure 6.1].

Figure 6.2 image description: Part A is a micrograph showing a cross section of thin skin. The topmost layer is a thin, translucent layer with irregular texture and areas where cells are sloughing off. The deepest layer is dark purple and extends into the third layer with finger like projections. The third light purple layer contains thin bands of fibers and small, dark cells. The fourth, and deepest layer, is darker than the third layer, but is still light purple. It contains thick fiber bands that are loosely packed. Part B is a magnified view of the epidermis of thick skin. It shows the topmost layer is five times thicker than the topmost layer of thin skin. The topmost layer of thick skin is also denser and less translucent than the topmost layer of thin skin. [Return to Figure 6.2].

Figure 6.3 image description: The outer layer of cells in this micrograph is the thinnest layer and stained deep purple due to full keratinization of dead cells. The next layer occupies one quarter of the micrograph, is lightly stained, and is a dense collection of cells. The third layer from the top is mostly white, with lightly stained, loosely-packed strands radiating in random directions. The bottom-most layer is densely-packed, with thick bands of highly organized muscle tissue that are darkly stained. [Return to Figure 6.3].

Figure 6.4 image description: This micrograph shows layers of skin in a cross section. The papillary layer of the dermis extends between the downward fingers of the darkly stained epidermis. The papillary layer appears finer than the reticular layer, consisting of smaller, densely-packed fibers. The reticular layer is three times thicker than the papillary layer and contains larger, thicker fibers. The fibers seem more loosely packed than those of the papillary layer, with some separated by empty spaces. Both layers of the dermis contain cells with darkly stained nuclei. [Return to Figure 6.4].

Figure 6.5 image description: Part A is a photo of a man skiing with several snow-covered trees in the background. Part B is a diagram with a right and left half. The left half is titled “ Heat is retained by the body,” while the right half is titled “Heat loss through radiation and convection.” Both show blood flowing from an artery through three capillary beds within the skin. The beds are arranged vertically, with the topmost bed located along the boundary of the dermis and epidermis. The bottommost bed is located deep in the hypodermis. The middle bed is evenly spaced between the topmost and bottommost beds. In each bed, oxygenated blood (red) enters the bed on the left and deoxygenated blood (blue) leaves the bed on the right. The left diagram shows a picture of snowflakes above the capillary beds, indicating that the weather is cold. Blood is only flowing through the deepest of the three capillary beds, as the upper beds are closed off to reduce heat loss from the outer layers of the skin. The right diagram shows a picture of the sun above the capillary beds, indicating that the weather is hot. Blood is flowing through all three capillary beds, allowing heat to radiate out of the blood, increasing heat loss. Part C is a photo of a man running through a forested trail on a summer day. [Return to Figure 6.5].

Figure 6.6 image description: A cross section of the skin containing a hair follicle. The follicle is teardrop shaped. Its enlarged base, labeled the hair bulb, is embedded in the hypodermis. The outermost layer of the follicle is the epidermis, which invaginates from the skin surface to envelope the follicle. Within the epidermis is the outer root sheath, which is only present on the hair bulb. It does not extend up the shaft of the hair. Within the outer root sheath is the inner root sheath. The inner root sheath extends about half of the way up the hair shaft, ending midway through the dermis. The hair matrix is the innermost layer. The hair matrix surrounds the bottom of the hair shaft where it is embedded within the hair bulb. The hair shaft, in itself, contains three layers: the outermost cuticle, a middle layer called the cortex, and an innermost layer called the medulla. [Return to Figure 6.6].

Figure 6.7 image description: The anatomy of the fingernail region. The top image shows a dorsal view of a finger. The proximal nail fold is the part underneath where the skin of the finger connects with the edge of the nail. The eponychium is a thin, pink layer between the white proximal edge of the nail (the lunula), and the edge of the finger skin. The lunula appears as a crescent-shaped white area at the proximal edge of the pink-shaded nail. The lateral nail folds are where the sides of the nail contact the finger skin. The distal edge of the nail is white and is called the free edge. An arrow indicates that the nail grows distally out from the proximal nail fold. The lower image shows a lateral view of the nail bed anatomy. In this view, one can see how the edge of the nail is located just proximal to the nail fold. This end of the nail, from which the nail grows, is called the nail root. [Return to Figure 6.7].

Figure 6.8 image description: An illustration of an eccrine sweat gland embedded in a cross section of skin tissue. The eccrine sweat gland is a bundle of white tubes embedded in the dermis. A single white tube travels up from the bundle and opens on to the surface of the epidermis. The opening is called a pore. There are several pores on the small block of skin portrayed in this diagram. [Return to Figure 6.8].

Figure 6.9 image description: This figure consists of two photos. One photo shows a young woman on the phone. Her skin is smooth and unwrinkled. The other photo shows an elderly women in the same posture while on the phone. The skin of her hands and forearms is wrinkled. [Return to Figure 6.9].

Figure 16.10 image description: Five photos of moles. The three upper photos show moles that are small, flat, and dark brown. The bottom left photo shows a dark black mole that is raised above the skin. The bottom right photo shows a large, raised, reddish mole with protruding hairs. [Return to Figure 6.10].

Figure 16.17 image description: This diagram depicts the percentage of the total body area burned when a victim suffers complete burns to regions of the body. Complete burning of the face, head and neck account for 19% of the total body area. Burning of the chest, abdomen and entire back above the waist accounts for 36% of the total body area. Anterior and posterior surfaces of the arms and hands account for 18% of the total body area (9% for each arm). The anterior and posterior surface of both legs, along with the buttocks, accounts for 36% of the total body area (18% for each leg). Finally, the anterior and posterior surfaces of the genitalia account for 1% of the total body area. [Return to Figure 6.17].

Unless otherwise indicated, this chapter contains material adapted from Anatomy and Physiology (on OpenStax), by Betts, et al. and is used under a a CC BY 4.0 international license. Download and access this book for free at https://openstax.org/books/anatomy-and-physiology/pages/1-introduction.

Sours: https://ecampusontario.pressbooks.pub/medicalterminology/chapter/integumentary-system/

What Is Sebum and How Does Your Skin Produce It?

Sebum is a yellowish, oily substance secreted by the aptly named sebaceous glands that are found on nearly every surface of the body. Due to its unique composition, sebum seals in moisture and prevents skin from becoming over dry. It also has antibacterial properties, making it the body’s first defense against infection.

As essential as sebum is to overall health and well-being, overproduction or underproduction of it—due to hormonal fluctuations, for example—are associated with skin problems including acne, oily skin, and chronic itchiness and skin irritation. 


Sebum Production

The sebaceous glands, each attached to a hair follicle, produce sebum through a process called holocrine secretion. The glands produce lipids, which remain inside the sac-like glands for about a week until the sac erupts, allowing the sebum to flow freely into the hair follicle. The hair then wicks the oil onto the skin to lubricate and protect it.

All babies are born with sebaceous glands over most of their bodies, with the exception of the palms of the hands, tops and soles of the feet, and lower lips.

These glands produce significant amounts of sebum right after birth. This is because the glands are regulated by hormones, particularly androgens (male sex hormones such as testosterone), which newborns have in abundance.

As a baby reaches toddlerhood, their hormone levels even out and the sebaceous glands become less active: Children produce very little sebum between ages 2 to 6. With the approach of puberty, androgens again flood the body and the glands pump out steady amounts of sebum.

Sebum production starts to decrease by age 20 and continues to slow with age.

The face, scalp, upper neck, and chest host the most sebaceous glands, so when there's a surge in sebum production, these areas are prone to acne breakouts or oily skin.

The size of these glands and the way hormones influence them are determined by genetics, so if you have close relatives with acne, dry skin, or other sebum-related conditions, you're more likely to suffer from the same problem.


Sebum is a complex fusion of lipids, mostly glycerides and free fatty acids with a substantial percentage of wax esters and squalene, plus a mix of cholesterol esters and cholesterol. 

Percentages of Lipids in Sebum
LipidPercentage in Sebum
Glycerides30% to 50%
Fatty acids15% to 30%
Wax esters26% to 30%
Squalene12% to 20%
Cholesterol esters3.0% to 6.0%
Cholesterol1.5% to 2.5%

These lipids work together to moisturize the skin and defend the body. Squalene and wax esters, for instance, create a protective barrier on the surface of the skin that helps seal in moisture and electrolytes.

Hydrolyzed triglycerides and free fatty acids (particularly sapienic acid) act as antimicrobial agents to keep out potentially harmful microbes and defend against infection.

Role of Sebum in Health

The disbursement of sebum all over the body supports the health of the skin in a number of important ways:

  • Hydration: Sebum is essential for pliable skin, but the levels of lipids secreted have to be properly balanced to prevent skin irritation. 
  • Antibacterial protection: Lipids secreted by sebaceous glands create a slightly acidic film on the skin—a pH of 4.5 to 6.0—which defends against bacteria, viruses, and other microbes.
  • Antifungal protection: Sebum has been shown to prevent fungal infections such as ringworm, which may explain why young children, who release little or no sebum, are especially susceptible to the skin disorder. 
  • Sun protection: Squalene has been shown to protect against sunburn and the damage caused by ultraviolet (UV) rays. 

Besides helping the skin, sebum also seems to support heart health. Researchers believe that a major benefit of sebum secretion is that the process eliminates excess lipids and cholesterol, which can block arteries and cause heart disease.

There is some research to suggest that adults who had acne as adolescents may have a lower risk of death from coronary heart disease because they regularly secreted lipids.


Sebum production is controlled by hormones, so if you have a hormone imbalance you might have too much sebum, which can cause a number of conditions.


Especially during adolescence, a spike in hormones can cause a spike in sebum production. An excess of sebum combined with dead skin cells can block pores and cause acne blemishes such as blackheads and pimples.

Acne often is effectively treated with topical creams or oral medications that contain retinoids, antibiotics, and/or hormones. 

Men undergoing testosterone replacement therapy are likely to have increased levels of sebum and therefore may be at increased risk of having acne.

Oily Skin

Excessive sebum also can cause oily skin. Oily skin may accompany acne, but it doesn’t always. While testosterone and progesterone are associated with acne, too much growth hormone is connected with sebum production that leads to oily skin. 

When skin is oily, facial pores look larger and skin may seem greasy and unclean. An appropriate facial cleansing routine may be sufficient for dealing with mildly oily skin.

For skin that's extremely oily, however, oral or topical retinoids (vitamin A derived compounds) and/or oral contraceptives may be necessary; these medications can have dangerous side effects for some people and should be used with caution and only with the guidance of a healthcare provider.

Seborrheic Dermatitis

An inflammatory skin disorder, seborrheic dermatitis can cause dandruff of the scalp as well as itchy, flaky, or scaly skin wherever there are overactive sebaceous glands.

Up to 3% of the general population has seborrheic dermatitis. Those with neurological disorders such as Parkinson’s disease and immunosuppressed persons, such as those with HIV/AIDS, are especially at risk.

Usual treatments include topical antifungal or anti-inflammatory creams or washes. Some alternative and homemade remedies may provide relief, but you should discuss these with your healthcare provider to ensure they are safe.

Seborrheic Dermatitis


Some medications for treating acne and oily skin work by suppressing sebum production; these include oral contraceptives, anti-androgens, and prescription retinoids (both orally and topical). If you have normal sebum levels to start with, you should be cautious using these medications.

Research also shows that products containing cannabidiol (CBD) may reduce sebum production. Studies have shown that CBD infused into the bloodstream has been effective for suppressing sebum, but more studies are needed to see if topical applications are also effective.

Sebum production can be severely impacted by eating disorders, severe fasting, and malnutrition. Within five days of significantly restricting calories, there’s a drop in sebum that can lead to a type of eczema called asteatosis. 

The most common problem associated with insufficient sebum is dry, red, flaky, and itchy skin that can be exacerbated by harsh soaps or frequent long hot baths or showers.

Mildly dry skin can be eased with a moisturizer containing ceramides, emollients, sorbitol, glycerin, or humectants. Thicker, greasier moisturizers containing ingredients like petroleum jelly and mineral oil can be even more effective but may clog pores.

The most effective way to apply a moisturizer to treat dry skin is to slather a generous layer right after bathing, while skin is still damp.

If your skin is mildly chapped, cracked, or oily, you might talk to your healthcare provider about the best moisturizer for your skin type. A trip to the drugstore may be all you need to maintain smooth, soft, healthy skin.

Thanks for your feedback!

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. Fischer H, Fumicz J, Rossiter H, Napirei M, Buchberger M, Tschachler E, Eckhart L. Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death. J Invest Dermatol. 2017;137(3):587-594. doi:10.1016/j.jid.2016.10.017

  2. Schneider M, Paus R. Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion. Int J Biochem Cell Biol. 2010;42(2):181-5. doi:10.1016/j.biocel.2010.11.017

  3. Bagatin E, de Freitas T, Machado M, Ribeiro B, Nunes S, da Rocha M. Adult female acne: a guide to clinical practice. An Bras Dermatol. 2019;94(1): 62–75. doi:10.1590%2Fabd1806-4841.20198203

  4. Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. Sebaceous gland lipids. Dermatoendocrinol. 2009;1(2):68-71. doi:10.4161%2Fderm.1.2.8472

  5. Lovászi M, Szegedi A, Zouboulis C, Törőcsik D. Sebaceous-immunobiology is orchestrated by sebum lipids. Dermatoendocrinol. 2017;9(1):e1375636. doi:10.1080/19381980.2017.1375636

  6. Zhou S, Li D, Zhou Y, Cao J. The skin function: a factor of anti-metabolic syndrome. Diabetol Metab Syndr. 2012;4(1):15. doi:10.1186/1758-5996-4-15

  7. Fox L, Csongradi C, Aucamp M, Du plessis J, Gerber M. Treatment Modalities for Acne. Molecules. 2016;21(8). doi:10.3390%2Fmolecules21081063

  8. Osterberg EC, Bernie AM, Ramasamy R. Risks of testosterone replacement therapy in men. Indian J Urol. 2014;30(1):2-7. doi:10.4103/0970-1591.124197

  9. Endly D, Miller R. Oily Skin: A review of Treatment Options. J Clin Aesthet Dermatol. 2017;10(8):49-55.

  10. Borda L, Wikramanayake T. Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J Clin Investig Dermatol. 2015;3(2). doi:10.13188/2373-1044.1000019

  11. Szöllősi A, Oláh A, Bíró T, Tóth B. Recent advances in the endocrinology of the sebaceous gland. Dermatoendocrinol. 2017;9(1):e1361576. doi:10.1080%2F19381980.2017.1361576

  12. Strumia R. Eating disorders and the skin. Clin Dermatol. 2013;31(1):80-5. doi:10.1016/j.clindermatol.2011.11.011

  13. Purnamawati S, Indrastuti N, Danarti R, Saefudin T. The role of moisturizers in addressing various kinds of dermatitis: A review. Clin Med Res. 2017;15(3-4):75-87.

Sours: https://www.verywellhealth.com/what-is-sebum-1069375
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Shared Flashcard Set

Skin, and accessory organs of hair, nails, and glands. FX: covers and protects all outer surfaces of the body, & has many vital fxs including sense of touch, protecting body against uv rays, regulating body temp, preventing dehydration, resevoir for food and water, synthesizes vitamin D..
Outer layer of the skin.  Consists of 5 layers, most important are statum corneum (contains dead flat cells that lack blood supply and sensory receptors), and basal layer (deepest layer and is the only layer of the epidermis that is composed of living cells where new cells are formed)
hard protein material that replaces cells that have been sloughed off.  Waterporrf characteristic of keratin prevents body fluids from evaporating and moisture from entering the body.
IN the basal layer, special cells called melanocytes produce a black pigment called melanin.  Melanin provides a protective barrier from the damaging efects of the sun's ultraviolet radiation, which can cause skin cancer.
2nd layer of the skin (also called corium), and is composed of living tissue and contains numerous capillaries, lymphatic vessels, and nerve endings.  Hair follicles, sebacceous glands, and sudoriferous (sweat) glands are also located in the dermis.
Subcutaneous layer (hypodermis)
binds the dermis to underlying structures & is composed of loose connective tissue and adipose tissue interlaced with blood vessels.  FX= stores fats, insulates and cushions the body, and regulates temperature.
Exocrine glands of the integumentary system
Sudoriferous (sweat) glands produce sweat on the skin through pores most plentiful on the palms, soles, forehead, and axillae and fx to cool the body by evaporation, excrete waste products, and moisten surface cells. Sebaceous (oil) glands are filled with cells whose centers contain fatty droplets.  As these cells disintegrate, they yield an oily secretion called sebum.  The acidic quality helps to destroy harmful orgainisms on the skin, preventing infection.  When ductules of sebaceous glands become blocked, acne may result.  Sex hormones androgens regulate production and secretion of sebum.  
Found everywehre on the body except lips, nipples, palms, soles, and parts of external genitalia.  VIsibile part of hair is the hair shaft, that embedded in the dermis is the hair root.  Root with coverings forms the hair follicle.  Bottom of the follicle is a loop of capillaries enclosed in a covering is called the papilla
baldness.  occurs when the hairs of the scalp are not replaced because of death of the papillae.
Protect the tips of fingers and toes from bruises and injuries.  Each nail is formed in the nail root and is composed of keratinized stratified squamous epithelial cells producing a very tough covering.  As the nail grows, it stays attached and slides forward over the layer of epithelium called the nail bed. The lunula is the region where new growth occurs.
Generic term for an agent (usually a hormone, such as testosterone and androsterone) that stimulates development of male characteristics.
formation of a complex substance by the union of simpler compounds or elements.


ex: adiposis (abnormal condition of fat)

lipocele: hernia containing fat

statitis: inflammation of fatty tissue



i.e.: subcutaneous (pertaining to beneath the skin

dermatoplasty: surgical repair of the skin

hypodermic: pertaining to under the skin



ex: hidradenitis: inflammation of the sweat glands

sudoresis: profuse sweating



ichthyosis: abnormal condition of dry or scaly skin (Ichtyosis can be any of several dermatological conditions in which the skin is dry and hardened, resembling fish scales.  A mild form of ichthyosis called winter itch, is commonly seen on the legs of older patients, esp. during the winter months).


horny tissue; hard; cornea

ex: keratosis: abnomal condition of horny tissue (Keratosis is a thickened area of the epidermis or any horrny growth on the skin, such as a callus or wart)



ex: melanoma: black tumor



ex: dermatomycosis: fungal infection of the skin



ex: onychomalacia: softening of the nails

ungual: pertaining to the nails



ex: pilonidal: pertaining to hair in a nest (nid-nest)

(a pilonidal cyst commonly develops in the skin at the base of the spine. It develops as a growth of hair in a dermoid cyst).


trichopathy: disease involving the hair


hardening: sclera (white of eye)

ex: scleroderma: hardening of the skin

Scleroderma is an autoimmune disorer that causes the skin and internal organs to become progressively hardened due to deposits of collagen. It may occur as a localized form or as a systemic disease


sebum, sebaceous

ex: seborrhea: discharge of sebum (Seborrhea is an excessive secretion of sebum from the sebaceous glands).



squamous: pertaining to scales (or covered with scales)


foriegn, strange

ex: xenograft: skin transplantation from a foriegn donor (usually a pig) for a human; also called heterograft.  Xenografts are used as a temporary graft to protect the patient agains infection and fluid loss



ex: xeroderma: dry skin (Xeroderma is a chronic skin condition characterized by dryness and roughness and is a mmild form of icthyosis).


without, not

ex: anhidrosis - abnormal condition of abscence of sweat


through, across

ex: diaphoresis: excessive or profuse sweating - phoresis = carrying transmission


excessive, above, normal

ex: hyperhidrosis: excessive or profuse sweatting.  also called diaphoresis or sudoresis


under, below

ex: subungual: pertaining to beneath the nail of a finger or toe (ungu-nail)

flat, pigmented, circumscribed area less than 1cm in diameter. examples include freckles, flat mole, or rash that occurs in rubella
Solid, elevated lesion less than 1cm in diameter that may be same color as the skin or pigmented. examples: nevus, wart, pimple, ringworm, psoriasis, eczema
palpable, circumscribed lesion, larger and deeper than a papule (0.6 - 2cm in diameter) extends into the dermal area: examples: intradermal nevus, benign or malignant tumor.
solid, elevated lesion larger than 2cm in diameter that extends into the dermal and subcutaneous layers: examples: lipoma, steatoma, dermatofibroma, hemangloma
elevated, ifrm, rounded lesion with localized skin edeam that vaires in shape and color, paler in the center than its surrounding edges, accompanied by itching. Examples: hives, insect bites
elevated, circumscribed fluid filled lesion less than 0.5cm in diameter.  Examples: poison ivy, shingles
Small, raised, crcumscribed lesion that contains pus, usually less, than 1cm in diameter: examples: acne, furuncle, pustular psoriasis, scabies

A vesicle or blister larger than 1 cm in diameter

examples: 2ndd degree burn, severe poison oak, poison

secondary lesions: excoriations
linear scratch marks or traumatized abrasions of the epidermis: ex. scratches, abrasions, chemical or thermal burns
Small slit or crack like sore that extends into the dermal layer, could be caused by continuous inflammation and drying
An open sore or lesion that extends to the dermis and usually heals with scarring.  Examples: pressure sore, basal cell carcinoma
least serious, only injure the epidermis, caused by brief contact with either dry or moist heat, sunburn, or exposure to chemicals.  Injury restricted to local effects, such as skin redness (erythema) and acute sensititvity to sensory stimuli (hyperestehesia). generally, blisters do not form and the burn heals without scar formation.
deep burns that damage both the epidermis and part of the dermis, caused by contact with flames, hot liquids, or chemicals. Symptoms same as 1st degree burns, but fluid-filled blisters (vesicles or bullae) form and the burn may heal with little or no scaring.
3rd degree burns (full thickness burns)
epidermis and dermis are destroyed and some fo the underlying connective tissue is damaged, leaving the skin wayxy and charred with insensitvity to touch. THe underlying bones, muscles, and tendons may also be damaged. caused by orrosive chemicals, flames, electricity, or extremely hot objects, immersion of the body in extremely hot water or clothing that catches fire. Because of the extensiveness of tissue destruction, ulcerating wounds develop and the body attempts to heal itself by forming scar tissue. 
localized collection of pus at the site of an infection (characteristically a staphylococcal infecection).  When a localized absces originates in a hair follicle, it is called a furnuncle or boil.  A cluster of furncles in the subcutaneous tissue resluts in the formation of a carbuncle.
Inflammatory disease of the sebaceous glands and hair follicles of the skin with characteristic lesions that include blackheads (comedos) inflammatory papules, pustules, nodules, and cysts, usually associated with seborrhea, also called acne vulgaris.  Acne results from thickening of the follicular opening, increased sebum production, and the presence of bacteria.  It is associated with an inflammatory response.  The face, neck, and shoulders are common sites for this condition.
Partial or complete loss of hair resulting from normal aging, an endocrine disorder, a drug reaction, anticancer medication, or a skin disease, commonly called baldness
Form of intraepidermal carcinoma (squamous cell) characterized by red brown scaly or cursted lesions that resemble a patch of psoriasis or dermatitis; also called Bowen precancerous dermatosis.  treatments include curettage and electrodesiccation.
Diffuse, acute infection of the skin and subcutaneous tisue.  Cellulitis is characterized by a light glossy appearance of the skin, localized heat, redness, pain, swelling and, occassionally, fever, malaise, and chills
Pigmentary skin discoloration usually occuring in yellowish brown patches or spots
Typical small skin lesion of acne vulgaris caused by acumulation of keratin, bacteria, and dried sebum plugging an excretory duct of the skin.  The closed form of comedo, called a whitehead, consists of a papule from which the contents are not easily expressed.
Infection of the skin caused by fungi (common example includes ringworm)
Skin discoloration consisting of a large, irregularly formed hemorrhagic area with colors changing from blue-black to greeninsh brown or yellow. Commonly called a bruise
Chronic skin inflammation characterized by erythema, papules, vesicles, pustules, scales, crusts, scabs, and possibly itching.
Redness of the skin caused by swelling of the capillaries (Example is mild sunburn or nervous blushing)
Damaged tissue following a severe burn.
Bacterial skin infection characterized by isolated pustules that become crusted and ruputre.
Thickened area of the epidermis or any horny growth on the skin (such as a callus or wart)
Small brown macules, especially on the face and arms,brought on by sun exposure, usually in a middle-aged or older person.  (these pigmented lesions of the skin are benign and no treatment is necessary unless cosmetic repair is ddesired)
Unnatural paleness or absence of color in the skin
INfestation with lice, transmitted by personal contact or common use of brushes, combs, or headgear (pedicul: lice)
Minute, pinpoint hemorrhage under the skin (Petechia is a smaller version of an ecchymosis)
Skin ulceration caused by prolonged pressure from lying in one posistion that prevents blood flow to the tissues, usually in bedridden patients; also known as decubitus ulcer.
Chronic skin disease characterized by circumscribed red patches covered by thick, dry, slivery adherent scales, caused by excesive development of the basal layer of the epidermis.  New psoriasis lesions tend to appear at sites of trauma. They may be found in any location, but commonly on scalp, knees, elbows, umbilicus, and genitalia.
ANy of several bleeding disorders characterized by hemorrhage into the tisues, particularly beneath the skin or mucous membranes, producing ecchymoses or petechiae.
Contagious skin disease transmitted y the itch mite, commonly through seual contact.  Scabies manifests as papules, vesicles, pustules, and burrows and causes intense itching commonly resulting in secondary infections.  The axillae, genitalia, inner aspect of the thights, and areas between the fingers are most commonly affected.
Fungal skin infection whose name commonly indicates the body part affected. Also called ringworm.  Examples include tinea barbae (beard), tinea corporis (body), tinea pedis (athlete's foot), tinea versicolor (skin) and tinea cruris (jock itch)
Allergic reaction of the skin characterized by the eruption of pale red, elevated patches called wheals or hives
Epidermal growth caused by a virus, also known as warts. Types include plantar warts, juvenile warts, and veneral warts.  Verrucae may be removed by cryosurgery, electrocautery, or acids, however, they may regrow if the virus remains in the skin
Localized loss of skin pigmentation characterized by milk white patches
Any test in which a suspected allergen or sensitizer is appied to or injected into the skin to determine the patient's sensitivity to it.
Skin test that identifies suspected allergens by subcutaneously injecting small amounts of extracts of the suspected allergens and observing the skin for a subsequent reaction.
Chemical removal of the outer layers of skin to treat acne scarring and general keratoses, also called chemabrasion
Removal of necrotized tissue from a wound by surgical excision, enzymes, or chemical agents.  Debridement is used to promote healing and prevent infection.
Rubbing (abrasion) using wire brushes or sandpaper to mechanically scrape away (abrade) the epidermis.  This procedure is used to remove acne scars, tattoos, and scar tissue.
Tissue destruction by means of high-frequency electric current. also called electrodesiccation.
Use of subfreezing temperature (commonly liquid nitrogen) to destroy or eliminate abnormal tissue, such as tumors, warts, and unwanted, cancerous, or infected tissue.
Incision and Drainage (I&D)
Process of cutting through a lesion such as an abscess and draining its contents.
Surgical procedure to transplant helathy tissue by applying it to an injured site. Human, animal, or artificial skin can be used to provide a temp. covering or permanent layer of skin over a wound or burn
Transplantation of healthy tissue from one person to another person, also called a homograft.  In an allograft, the donor is usually a cadaver. 
Transplantation of healthy tisssue from one site to another site in the same individual
Transplantation of artificial skin produced from collagen fibers arranged in a lattice pattern.  The recipient's body does not reject synthetic skin (produced artificially) and healing skin grows into it as the graft gradually disintegrates.
Transplantation (dermis only) from a foriegn donor (usually a pig) and transferred to a human; also called heterograft.  A xenograft is used as a temp graft to protect the patient against infections and fluid loss.
Sours: https://www.flashcardmachine.com/medical-termchap5.html
SO MUCH Deep Whitehead \u0026 Sebum Extractions! Macro View

Sebaceous filaments: What to know

Beneath the skin’s surface lie tiny glands that create sebum, an oily substance that helps lubricate the skin. Sebaceous filaments are structures that allow sebum to flow to the surface of the skin.

When the body overproduces sebum, the sebaceous filaments can fill up. They may become visible and resemble very enlarged pores.

People often confuse sebaceous filaments with blackheads. Blackheads are a form of acne.

Sebaceous filaments are not a type of acne, they are normal structures within the skin.

However, the overproduction of sebum that causes sebaceous filaments to fill up and become noticeable can also cause whiteheads or blackheads.

In this article, we look at how sebaceous filaments become visible. We also describe the differences between sebaceous filaments and blackheads, treatments for each, and when it might be a good idea to consult a doctor.

Differences from blackheads

When sebaceous filaments are noticeable, they can look like enlarged, darkened pores. A person might easily confuse them for blackheads.

The key differences between blackheads and sebaceous filaments involve their:


A blackhead is a blockage or plug at the top of a pore. The plug prevents oil from escaping through the pore.

A sebaceous filament is a thin, hair-like structure that lines the inside of the pore and helps sebum travel to the skin’s surface. It has no plug.

Appearance and color

A noticeable sebaceous filament may look like a dark dot on the skin. The dot may resemble the head of a pin, and it may be yellow, gray, or clear.

A blackhead is a very dark plug at the top of a pore. The dark color develops when the plug is oxidized through contact with the air.


If a person squeezes, or “extracts,” a sebaceous filament, a white or yellow worm-like structure may ooze out. Or, the filament may not produce anything.

Trying to extract sebaceous filaments can injure the skin and cause scarring. It can also damage and stretch the pore, making it appear bigger.

When a person extracts a blackhead, the dark plug may come off. Beneath it, there may be white or yellow sebum and skin cells.

The American Academy of Dermatology advise against squeezing or popping acne of any kind.


The skin’s normal process of producing sebum can cause sebaceous filaments to become noticeable.

This is more likely to occur in people with more oily skin or larger pores, compared with people who have drier skin and smaller pores.

can determine pore size, including:

  • age
  • genetics
  • having thicker hair follicles
  • sun exposure

Visible sebaceous filaments are not a sign that the skin is dirty.


Controlling the amount of oil on the skin and using exfoliating skin care products can help keep the pores clear. This may minimize the appearance of sebaceous filaments.

Use gentle products that cleanse the skin to prevent overdrying and irritation. The best product will depend on the person’s skin type.

No skin care product can completely get rid of noticeable sebaceous filaments. However, the following ingredients and approaches can help reduce their appearance:

Salicylic acid

Salicylic acid, also known as beta hydroxy acid, is an ingredient in many facial cleansers and acne creams. These products may contain 0.5% to 2.0% percent salicylic acid.

This type of acid may help reduce the amount of oil on the skin and the size of sebaceous filaments. Salicylic acid is , which means that it can penetrate sebum and help clear pores.

If a person has not used a product with salicylic acid before, it may be a good idea to start with one application every day or every other day. If dryness or peeling occurs, use the product less often.

Dermatologists can apply salicylic acid peels that are stronger than over-the-counter products. These peels may provide a more dramatic difference in pore size and appearance. They contain 15–50% salicylic acid.

Salicylic acid is a derivative of aspirin, so anyone who is allergic to aspirin should not use it.

Benzoyl peroxide

Benzoyl peroxide is a common ingredient in acne products. It can help dry the skin and limit the amount of oil, and it may reduce the size of pores.

Benzoyl peroxide can cause excessive dryness and peeling, however, especially at higher concentrations. Anyone who experiences this should use products containing benzoyl peroxide less frequently. Or, switch to products with lower concentrations of the ingredient.

Tea tree oil

Tea tree oil is an essential oil that people often use to treat acne. A small 2016 study suggests that tea tree oil may also help with oily skin.

It can, however, cause irritation and allergic reactions. Tea tree oil has the of any essential oil.

Anyone who is applying tea tree oil directly to the skin should dilute it to a strength of 5%.

Seek immediate medical care if signs of an allergic reaction occur, such as hives, swelling, or trouble breathing.

Sun protection

A suggests that long-term sun exposure can make the pores larger, which may lead to more noticeable sebaceous filaments. Sun exposure also increases the risk of skin damage and skin cancer.

Using sunscreen every day can help minimize the adverse effects of exposure and help keep the skin healthy.

People with oily skin and large pores may prefer to use sunscreen that is oil-free and noncomedogenic, meaning that it does not clog pores. Using greasy or heavy sunscreen could make large pores more noticeable.

Also, it is a good idea to wear a protective hat and clothing that covers the skin when spending extended periods in the sun.


The AAD say it is important to strike the right balance between having too much oil on the skin and maintaining the skin’s natural moisture.

It offers the following tips for controlling oily skin:

  • wash the face every morning, evening, and after exercise
  • avoid scrubbing, which will irritate the skin and can make it look worse
  • use skincare products, such as cleansers, moisturizers, and make-up, labeled “oil-free” or “non-comedogenic,” which are less likely to clog pores
  • moisturize every day to keep the skin hydrated
  • opt for a gentle, foaming face wash, as harsh products dry out the skin prompting it to produce more oil
  • avoid oil- or alcohol-based cleansers as these can irritate the skin


In extremely rare cases, some people can develop sebaceous gland carcinoma.

This rare type of cancer can occur anywhere on the body, including the head, neck, trunk, or genitals but tends to appear on the upper eyelid or around the eye.

The carcinomas look like firm, yellowish lumps, and they do not hurt. The condition is more common in older people and those who have had previous radiotherapy on the face.

Doctors will usually use surgery to remove the lumps. People may also need radiotherapy.

When to see a doctor

If over-the-counter products and a good skin care routine are not giving satisfactory results, a person may wish to see a dermatologist.

Dermatologists can prescribe more powerful medications for reducing oil production, leading to fewer noticeable sebaceous filaments.


Unlike blackheads and whiteheads, sebaceous filaments do not block pores.

Sebaceous glands are oil-producing glands in the skin. This oil, called sebum, travels to the outer layer of skin, or the epidermis, through the hair follicles. Sebum keeps the skin moist and healthy.

The resulting hair-like cylinders of a yellowish substance are harmless, though many people do not like the way they look.

By controlling oily skin, people can prevent or reduce the occurrence of sebaceous glands.

Sours: https://www.medicalnewstoday.com/articles/sebaceous-filaments

Or discharge sebum flow of

What is the correct medical term for discharge of sebum?

Sebum is the medical term for an oily secretion from the sebaceous glands in the skin; the latter word can also be an adjective referring more generally to oil or fat; seborrhoea (US seborrhea) (Greek rhoia, flow or flux) is excessive discharge of sebum from the sebaceous glands; sebacic acid is a white crystalline …

What does sebum mean in medical terms?

fatty lubricant matter

Which word part means sebum?

Origin of sebum First recorded in 1700–10, sebum is from the Latin word sēbum tallow, grease.

What causes sebum?

Sebum is produced by sebaceous glands when they disintegrate. The gland cells last about a week, from formation to discharge. The sebaceous glands produce lipids, triglycerides, which are broken down by bacterial enzymes (lipases) in the sebaceous duct to form smaller compounds, free fatty acids.

What gets rid of sebum?

Use a mild face cleanser and keep the rest of your body clean, too, especially areas that may be prone to acne.

  • Exfoliate. If you have a sebum plug of some kind, gently exfoliating dead skin cells may help keep the acne from worsening.
  • Use topicals.
  • Try oral medication.

How can I lower my sebum naturally?


  1. Wash regularly. Share on Pinterest Washing with warm water and a gentle soap can reduce the amount of oil on the skin.
  2. Use a toner. Astringent toners that contain alcohol tend to dry out the skin.
  3. Pat the face dry.
  4. Use blotting papers and medicated pads.
  5. Use a facial mask.
  6. Apply moisturizers.

What vitamins reduce sebum production?

A Few Ways To Help Fight Acne

  • Vitamin A. Vitamin A counters the adverse effects acne has on the skin.
  • Vitamin D. Vitamin D boosts the immune system and has antimicrobial properties.
  • Zinc. Zinc has been found to decrease the production of oil in the skin.
  • Vitamin E.

What foods reduce sebum production?

Foods rich in omega-3 fatty acids include:

  • fish, such as mackerel, salmon, and sardines.
  • pastured eggs.
  • soybeans and soy products, such as tofu.
  • spinach and kale.
  • navy beans.
  • grass-fed beef.
  • nuts, such as walnuts and almonds.
  • flaxseeds.

What foods produce more sebum?

This article will review 7 foods that can cause acne and discuss why the quality of your diet is important.

  • Refined Grains and Sugars.
  • Dairy Products.
  • Fast Food.
  • Foods Rich in Omega-6 Fats.
  • Chocolate.
  • Whey Protein Powder.
  • Foods You’re Sensitive To.

Does dairy cause sebum production?

Growth hormones Also, several studies indicate that milk consumption increases levels of IGF-1 in the blood by 9–20% in children aged 10–12 years. IGF-1 may increase sebum production. Sebum is an oil in the skin that may block pores and cause acne.

What foods cause high testosterone?

8 Testosterone-Boosting Foods

  • Tuna.
  • Low-fat milk.
  • Egg yolks.
  • Fortified cereals.
  • Oysters.
  • Shellfish.
  • Beef.
  • Beans.

Does diet affect sebum?

There are also studies claiming that sebum production is increased by the consumption of dietary fat or carbohydrate50 and that variations in carbohydrates could also affect sebum composition. In general our Western diet is not only deprived of omega- 3s but is also a diet rich in refined carbohydrates.

How do I get rid of oily skin forever?

Here are 10 remedies for oily skin you can try at home.

  1. Wash your face. It seems obvious, but many people with oily skin don’t wash their face daily.
  2. Blotting papers.
  3. Honey.
  4. Cosmetic clay.
  5. Oatmeal.
  6. Egg whites and lemons.
  7. Almonds.
  8. Aloe vera.

Does alcohol increase sebum production?

Alcohol and your hormones It can also increase estradiol levels in women, too. Estradiol is a form of estrogen. Increased hormone levels can stimulate your oil glands. Increased oil, or sebum, production can clog your pores and result in a breakout.

Does sugar increase sebum production?

Together, they can contribute to greater keratinocyte proliferation and sebum production, leading to acne. Therefore, a diet high in sugar and refined, heavily processed foods may exacerbate acne presentation, while a low glycaemic, whole food diet may reduce the severity and used in treatment and symptom prevention.

Can you reverse alcohol damage skin?

Your skin will definitely reap from the benefits of going sober for good: according to Dr. Mauricio, since your liver will be significantly repaired from the damages of alcohol by this point, your skin will have an overall healthier appearance and naturally radiant look.

Which alcohol is best for inflammation?

Red wine has greater anti-inflammatory action than other alcohols. indeed have heart health benefits over other alcoholic drinks.

Sours: https://www.mvorganizing.org/what-is-the-correct-medical-term-for-discharge-of-sebum/
How To Remove Excess Sebum In The Scalp For HAIR LOSS

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